Trivalent chromium compounds, compositions and methods of use
View Patent ↗The present invention provides chromium compounds, specifically chromium dinicocysteinate, which possess the ability to improve insulin sensitization, glucose tolerance, bioavailability, efficacy, and safety, and methods for their use.
1. A method for treating diabetes, the method comprising administering a biologically effective amount of a composition comprising an isolated and purified complex of trivalent chromium dinicocysteinate to a subject in need thereof.
2. The method of claim 1 , wherein the biologically effective amount increases vitamin C levels.
3. The method of claim 1 , wherein the biologically effective amount comprises about 10 μg to about 1000 μg of elemental chromium.
4. The method of claim 1 , wherein the composition is administered daily.
5. The method of claim 1 , wherein the biologically effective amount comprises about 400 μg of elemental chromium.
6. The method of claim 1 , wherein the subject is a mammal.
7. The method of claim 6 , wherein the mammal is human.
8. The method of claim 6 , wherein the mammal is a swine.
9. The method of claim 1 , wherein the subject is avian.
10. A method for treating symptoms associated with diabetes or with the onset of diabetes, the method comprising administering a biologically effective amount of a composition comprising an isolated and purified complex of trivalent chromium dinicocysteinate to a subject suffering from symptoms associated with diabetes or with the onset of diabetes.
11. The method of claim 10 , wherein symptoms associated with diabetes or with the onset of diabetes are treated by lowering the blood levels of one or more of fasting glucose, glycosylated hemoglobin, monocyte chemotactic protein-1, intracellular adhesion molecule, and red blood cell lipid peroxidase.
12. The method of claim 10 , wherein symptoms associated with diabetes or with the onset of diabetes are treated by increasing the blood levels of one or both of vitamin C and adiponectin.
13. A method for treating symptoms associated with atherosclerosis, the method comprising administering a biologically effective amount of a composition comprising an isolated and purified complex of trivalent chromium dinicocysteinate to a subject suffering from atherosclerosis.
14. A method for treating symptoms associated with cardiovascular disease, the method comprising administering a biologically effective amount of a composition comprising an isolated and purified complex of trivalent chromium dinicocysteinate to a subject suffering from symptoms associated with cardiovascular disease.
15. The method of claim 14 , wherein symptoms associated with cardiovascular disease are treated by lowering elevated LDL cholesterol, VLDL cholesterol, triglycerides, C-reactive protein, blood pressure and/or vascular inflammation levels, and/or increasing HDL cholesterol levels.