Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors

1. A compound of any one of the following Formulae (III) to(VIII):

or a pharmaceutically acceptable salt thereof, wherein:

R 3 is C 1-6 alkyl, Cy, or -L-Cy;

L is unsubstituted C 1-6 alkylene or C 1-6 alkylene substituted with 1, 2 or 3 substituents independently selected from F, Cl, CN, OH and O(C 1-6 alkyl);

Cy is unsubstituted or substituted C 6-10 aryl, unsubstituted or substituted 5-10 membered heteroaryl, unsubstituted or substituted C 3-6 cycloalkyl or unsubstituted or substituted 4-11 membered heterocycloalkyl,

wherein the substituted C 6-10 aryl, 5-10 membered heteroaryl, C 3-6 cycloalkyl or 4-11 membered heterocycloalkyl forming Cy is substituted with 1, 2, or 3 substituents each independently selected from halogen, R Cy1 , C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-7 membered heterocycloalkyl, C 1-6 haloalkyl, CN, OH, and C 1-6 alkoxy;

wherein each R Cy1 is, independently, C 1-6 alkyl, each of which is independently unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, CN, and OR a1 ; and

wherein R a1 is independently, at each occurrence, selected from H, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is C 1-6 alkyl.

3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 3 is ethyl or isopropyl.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is Cy.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is -L-Cy.

6. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted C 6-10 aryl.

7. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted phenyl.

8. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein Cy is substituted phenyl.

9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof, wherein Cy is phenyl substituted with 1, 2, or 3 substituents.

10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein Cy is phenyl substituted with 1, 2, or 3 substituents independently selected from halogen, CN, and OR a1 .

11. The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein Cy is phenyl substituted with 1, 2, or 3 substituents independently selected from fluoro, CN, and OH.

12. The compound of claim 11 , or a pharmaceutically acceptable salt thereof, wherein Cy is 2-cyanophenyl, 2,6-difluorophenyl or 2,6-difluoro-4-methoxyphenyl.

13. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted 5-10 membered heteroaryl.

14. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted 5-10 membered heteroaryl, the ring atoms of which consist of carbon atoms and 1 or 2 nitrogen atoms.

15. The compound of claim 14 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted pyridinyl or pyrazolyl.

16. The compound of claim 15 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted pyridinyl.

17. The compound of claim 16 , or a pharmaceutically acceptable salt thereof, wherein Cy is pyridinyl substituted with 1 substituent selected from C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-7 membered heterocycloalkyl, OH, and C 1-6 alkoxy.

18. The compound of claim 17 , or a pharmaceutically acceptable salt thereof, wherein Cy is 6-(morpholin-4-yl)pyridin-3-yl or 6-methoxypyridin-3-yl.

19. The compound of claim 15 , or a pharmaceutically acceptable salt thereof, wherein Cy is pyrazolyl substituted with a C 1-6 alkyl group.

20. The compound of claim 19 , or a pharmaceutically acceptable salt thereof, wherein Cy is 1-methyl-1H-pyrazol-4-yl or 1-ethyl-1H-pyrazol-4-yl.

21. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted C 3-6 cycloalkyl.

22. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted 4-11 membered heterocycloalkyl.

23. The compound of claim 22 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted heterocycloalkyl, the ring atoms of which consist of carbon atoms and 1, 2, or 3 heteroatoms independently selected from N and O.

24. The compound of claim 23 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted heterocycloalkyl, the ring atoms or which consist of carbon atoms and 1 or 2 nitrogen atoms.

25. The compound claim 23 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted heterocycloalkyl, the ring atoms of which consist of carbon atoms, 1 oxygen atom and 1 nitrogen atom.

26. The compound of claim 22 , or a pharmaceutically acceptable salt thereof, wherein a nitrogen atom of Cy forms the bond between Cy and the remainder of the molecule.

27. The compound of claim 24 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted pyrrolidinyl, piperidinyl, azetidinyl, piperazinyl or oxopiperazinyl.

28. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted pyrrolidin-1-yl.

29. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is pyrrolidin-1-yl substituted with a C 1-6 haloalkyl group.

30. The compound of claim 29 , or a pharmaceutically acceptable salt thereof, wherein Cy is 3-(trifluoromethyl)pyrrolidin-1-yl.

31. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted piperidin-1-yl.

32. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is substituted piperidin-1-yl substituted at the 4-position.

33. The compound of claim 32 , or a pharmaceutically acceptable salt thereof, wherein Cy is substituted piperidin-1-yl substituted at the 4-position by 1 substituent.

34. The compound of claim 32 , or a pharmaceutically acceptable salt thereof, wherein Cy is substituted piperidin-1-yl substituted by 1 substituent selected from R Cy2 , CN, and OR a .

35. The compound of claim 34 , or a pharmaceutically acceptable salt thereof, wherein Cy is 4-hydroxypiperidin-1-yl, 4-cyanopiperidin-1-yl, 4-methoxypiperidin-1-yl, 4-(pyridin-4-yl)piperidin-1-yl, or 4-(morpholin-4-yl)piperidin-1-yl.

36. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted azetidin-1-yl.

37. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is azetidin-1-yl substituted with two C 1-6 alkyl groups.

38. The compound of claim 37 , or a pharmaceutically acceptable salt thereof, wherein Cy is 3,3-dimethylazetidin-1-yl.

39. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted piperazin-1-yl.

40. The compound of claim 39 , or a pharmaceutically acceptable salt thereof, wherein Cy is 4-substituted piperazin-1-yl.

41. The compound of claim 39 , or a pharmaceutically acceptable salt thereof, wherein Cy is a piperazin-1-yl substituted with at least one C 1-6 alkyl.

42. The compound of claim 39 , or a pharmaceutically acceptable salt thereof, wherein Cy is piperazin-1-yl substituted only at the 4-position.

43. The compound of claim 42 , or a pharmaceutically acceptable salt thereof, wherein Cy is piperazin-1-yl substituted only at the 4-position and wherein the 4-substituent is C 1-6 alkyl.

44. The compound of claim 43 , or a pharmaceutically acceptable salt thereof, wherein Cy is 4-methylpiperazin-1-yl or 4-ethylpiperazin-1-yl.

45. The compound of claim 27 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted oxopiperazinyl.

46. The compound of claim 45 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted 3-oxopiperazin-1-yl.

47. The compound of claim 46 , or a pharmaceutically acceptable salt thereof, wherein Cy is 3-oxopiperazin-1-yl substituted only at the 4-position and wherein the 4-substituent is C 1-6 alkyl.

48. The compound of claim 47 , or a pharmaceutically acceptable salt thereof, wherein Cy is 4-methyl-3-oxopiperazin-1-yl or 4-ethyl-3-oxopiperazin-1-yl.

49. The compound of claim 25 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted 3-oxa-9-azaspiro[5.5]undecanyl, 1-oxa-8-azaspiro[4.5]decanyl, or morpholinyl.

50. The compound of claim 49 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted 3-oxa-9-azaspiro[5.5]undecan-9-yl, 1-oxa-8-azaspiro[4.5]decan-8-yl or morpholin-4-yl.

51. The compound of claim 23 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted heterocycloalkyl, the ring atoms of which consist of carbon atoms and 1 oxygen atom.

52. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted or substituted tetrahydro-2H-pyranyl.

53. The compound of claim 52 , or a pharmaceutically acceptable salt thereof, wherein Cy is unsubstituted tetrahydro-2H-pyran-4-yl.

54. The compound of claim 1 , wherein L is unsubstituted C 1-6 alkylene.

55. The compound of claim 54 , wherein L is CH 2 .

56. The compound of claim 1 , wherein each R Cy1 is methyl or ethyl.

57. The compound of claim 1 , wherein Cy is substituted with a 4 to 7 membered heterocycloalkyl.

58. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R a1 is selected from H and C 1-6 alkyl.

59. A compound selected from the following compounds, or a pharmaceutically acceptable salt thereof:

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluorophenyl) -1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropyl-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(tetrahydro-2H-pyran-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluoro-4-methoxyphenyl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropenyl-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-yl-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-ethylquinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropylquinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(tetrahydro-2H-pyran-4-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-ylquinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-ylquinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methylpiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methylpiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-pyridin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-pyridin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-ethyl-3-oxopiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-ethyl-3-oxopiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methoxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methoxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-morpholin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-morpholin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-pyrrolidin-1-ylquinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-pyrrolidin-1-ylquinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3,3-dimethylazetidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3,3-dimethylazetidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-azetidin-1-ylquinoline-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluoro-4-methoxyphenyl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(6-morpholin-4-ylpyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-oxa-8-azaspiro[4.5]dec-8-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)quinoline-2-carboxamide;

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-morpholin-4-ylpyridin-3-yl)quinoline-2-carboxamide;

N-(4-(3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-7-(pyridin-3-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2-cyanophenyl)quinoline-2-carboxamide;

N-(4-(3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-7-(4-hydroxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-7-(2-cyanophenyl)-1,5-naphthyridine-2-carboxamide; and

N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[6-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]quinoline-2-carboxamide.

60. The compound selected from the following compounds, or a pharmaceutically acceptable salt thereof:

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluorophenyl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropyl-1,5-naphthyridine-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(tetrahydro-2H-pyran-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluoro-4-methoxyphenyl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropenyl-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-yl-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-ethylquinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-isopropylquinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(tetrahydro-2H-pyran-4-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-ylquinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-ylquinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methylpiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methylpiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-pyridin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-pyridin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-ethyl-3-oxopiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-ethyl-3-oxopiperazin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methoxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methoxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-morpholin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-morpholin-4-ylpiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-pyrrolidin-1-ylquinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-pyrrolidin-1-ylquinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3,3-dimethylazetidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(3,3-dimethylazetidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-azetidin-1-ylquinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(2,6-difluoro-4-methoxyphenyl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(6-morpholin-4-ylpyridin-3-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(3-oxa-9-azaspiro[5.5]undec-9-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(4-cyanopiperidin-1-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-oxa-8-azaspiro[4.5]dec-8-yl)-1,5-naphthyridine-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-methoxypyridin-3-yl)quinoline-2-carboxamide;

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(6-morpholin-4-ylpyridin-3-yl)quinoline-2-carboxamide;

N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-7-(pyridin-3-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(1-methyl-1H-pyrazol-4-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(2-cyanophenyl)quinoline-2-carboxamide;

N-(4-((3S,5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-7-(4-hydroxypiperidin-1-yl)quinoline-2-carboxamide;

N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-7-(2-cyanophenyl)-1,5-naphthyridine-2-carboxamide; and

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-[6-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-yl]quinoline-2-carboxamide.

61. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

62. A method of inhibiting Pim1, Pim2 or Pim3 enzyme comprising contacting the enzyme with a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

63. A compound which is N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-morpholin-4-ylquinoline-2-carboxamide, or a pharmaceutically acceptable salt thereof.

64. A composition comprising the compound of claim 63 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.