Vaccine and methods for detecting and preventing filariasis
The present invention is a multivalent vaccine for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent vaccine are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.
1. A fusion protein comprising a Brugia malayi Abundant Larval Transcript of SEQ ID NO:37; a Brugia malayi Small heat shock protein 12.6 of SEQ ID NO:49, a Brugia malayi Tetraspanin of SEQ ID NO:63, and a Brugia malayi Thioredoxin Peroxidase 2 of SEQ ID NO:71.
2. The fusion protein of claim 1 , wherein said fusion protein comprises SEQ ID NO:74.
3. A vaccine for providing protective immunity against Brugia malayi comprising the fusion protein of claim 2 and an adjuvant.