Process for the preparation of an orexin receptor antagonist

Inventors: Carl A. Baxter (London, GB); Faye Sheen (Hoddesdon, GB)

Assignee: Merck Sharp & Dohme (UK) Ltd.

C07D413/14 A61K31/55 C07D249/06 C07D413/04

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Quick Facts

Patent No.: US 11,401,266
App. No.: 14/801,424
Granted: Aug 2, 2022
Kind: B2

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Abstract

The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Claims (4)

1. A compound which is:

or a salt thereof.

2. The compound of claim 1 which is:

3. A compound which is:

Assignments (5)

CHANGE OF ADDRESS Recorded Sep 13, 2022

From: MERCK SHARP & DOHME (UK) LIMITED

To: MERCK SHARP & DOHME (UK) LIMITED

Reel/Frame 061419/0898 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2022

From: KRSKA, SHANE W.; STROTMAN, NEIL; WRIGHT, TIMOTHY; WALLACE, DEBRA J.