Stabilization of vitamin B
View Patent ↗The invention relates to preparations comprising vitamin B 12 and a butanol, and to the use of butanol for stabilizing vitamins.
1. A photostable vitamin B 12 formulation comprising:
0.001 to 0.01% m/V vitamin B 12 ;
butaphosphan;
0.5 to 7% n-butanol m/V; and
water,
wherein the pH of the formulation is from about 4 to about 7.
2. The formulation of claim 1 comprising from 1 to 5% m/V n-butanol.
3. The formulation of claim 1 comprising from 2 to 4% m/V n-butanol.
4. The formulation of claim 1 comprising from 0.005 to 0.01% m/V vitamin B 12 .
5. The formulation of claim 1 comprising from 1 to 30% m/V butaphosphan.
6. The formulation of claim 1 comprising from 5 to 20% m/V butaphosphan.
7. The formulation of claim 2 comprising from 5 to 20% m/V butaphosphan.
8. The formulation of claim 1 , wherein the pH of the formulation is 5.6±0.2.
9. The formulation of claim 7 , wherein the pH of the formulation is 5.6±0.2.
10. The formulation of claim 1 , wherein the vitamin B 12 is cyanocobalamin.
11. The formulation of claim 7 , wherein the vitamin B 12 is cyanocobalamin.
12. The formulation of claim 1 further comprising a base.
13. The formulation of claim 11 further comprising a base.
14. The formulation of claim 13 , wherein the base comprises sodium hydroxide.
15. The formulation of claim 1 , wherein water constitutes over 75% m/V of the formulation.
16. The formulation of claim 11 , wherein water constitutes over 75% m/V of the formulation.
17. The formulation of claim 1 further comprising a cosolvent.
18. The formulation of claim 1 further comprising an antioxidant, wetting agent, or combinations thereof.