Dermal compositions
Disclosed herein are veterinary compositions including imidacloprid or an analogue thereof; a pyrethroid; a solvent selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and dimethyl sulfoxide. The veterinary compositions of the invention are useful in methods of controlling parasites on or within warm-blooded domesticated animals.
1. A veterinary composition comprising:
2.5% to 12.5% by weight of imidacloprid;
35% to 67.5% by weight of permethrin;
0.1% to 2% by weight of pyriproxyfen; and solvents consisting of
21% to 23% by weight of a first solvent selected from the group consisting of N-methyl pyrrolidone, N-ethyl pyrrolidone and mixtures thereof; and
15% to less than 20% by weight of a second solvent which is dimethyl sulfoxide (DMSO).
2. The veterinary composition according to claim 1 which comprises 17% to 19% by weight of DMSO.
3. The veterinary composition according to claim 1 wherein the first solvent is N-methyl pyrrolidone.
4. The veterinary composition according to claim 1 which further comprises an antioxidant in an amount in the range from about 0.05% to about 0.25% by weight.
5. The veterinary composition according to claim 1 which further comprises at least one organic acid in an amount in the range from about 0.05% to about 1% by weight.