RAPID, PRECISE, NITRIC OXIDE ANALYSIS AND TITRATION APPARATUS AND METHOD

1 . A system for precisely delivering nitric oxide, the system comprising:

a ventilator delivering breathing air;

a source of nitric oxide;

a mixer combining the nitric oxide and the breathing air into a breathing mixture;

a detector comprising a manifold receiving a portion of the breathing mixture, at least one sensor, capable of sensing at least one of oxygen, nitric oxide, and another oxide of nitrogen, and a diverter vectoring the portion of the breathing mixture toward the at least one sensor; and

the detector, wherein the diverter is sized, shaped, and positioned to reduce an aerodynamic boundary layer of the portion of the breathing mixture proximate the at least one sensor.

2 . The apparatus of claim 1 , further comprising:

a metering valve controlling delivery of the nitric oxide; and

a processor operably connected to the metering valve and the at least one sensor to control the delivery of the nitric oxide based on data obtained from the at least one sensor.

3 . The apparatus of claim 2 , wherein the processor is programmed to control the metering valve to approach a set point monotonically.

4 . A method for precisely delivering nitric oxide, the system comprising:

providing a ventilator delivering breathing air;

providing a source of nitric oxide;

providing a mixer combining the nitric oxide and the breathing air into a breathing mixture;

providing a detector comprising a manifold receiving a portion of the breathing mixture, at least one sensor, capable of sensing at least one of oxygen, nitric oxide, and another oxide of nitrogen, and a diverter vectoring the portion of the breathing mixture toward the at least one sensor;

the providing the detector, wherein the diverter is sized, shaped, and positioned to reduce an aerodynamic boundary layer of the portion of the breathing mixture proximate the at least one sensor; and

providing control of a fraction of nitric oxide in the breathing mixture based on an output from the detector provided to the source of nitric oxide.

5 . The method of claim 4 , further comprising:

providing a metering valve controlling delivery of the nitric oxide;

providing a processor operably connected to the metering valve and the at least one sensor to control the delivery of the nitric oxide based on data obtained from the at least one sensor; and

automatically controlling the metering valve by the processor, based on the output from the detector.

6 . The method of a claim 5 , wherein the processor is programmed to control the metering valve to approach a set point monotonically.

7 . A method of administering nitric oxide, the method comprising:

pumping a filtered gas into a reaction chamber;

providing a mixture of reactants comprising at least a calcine chromium oxide compound, a nitrite compound and a nitrate compound in the reaction chamber;

activating the reactants to initiate a reaction generating a nitric oxide gas;

evacuating the nitric oxide gas away from the reaction chamber in a closed conduit to inhibit further heating thereof and to resist further reaction of the nitric oxide gas;

filtering the nitric oxide gas; and

delivering the nitric oxide at substantially ambient conditions to a user to provide a therapeutically safe concentration of nitric oxide.

8 . The method of claim 7 , wherein the delivering of nitric oxide is controlled automatically by a processor based on downstream detection of the constitution of the nitric oxide mixed with air.

9 . The method of claim 8 , wherein a diverter improves at least one of speed and accuracy of the downstream detection by reducing a boundary layer near a sensor in the detector through vectoring a flow of the nitric oxide mixed with the air.