IP Library › Granted Patent US 9,932,479
Granted Patent B2
US 9,932,479 · App. 14/812,171 · Granted Apr 3, 2018

Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications

Inventors: Wayne Forrest Patton (Dix Hills, NY); Sergiy M. Yarmoluk (Kyiv, UA); Praveen Pande (Holbrook, NY); Vladyslava Kovalska (Kyiv, UA); Lijun Dai (Farmingville, NY); Kateryna Volkova (Kyiv, UA); Jack Coleman (East Northport, NY); Mykhaylo Losytskyy (Kyiv, UA); Anthony Ludlum (Ypsilanti, MI); Anatoliy Balanda (Kyiv, UA)
Assignee: Enzo Biochem, Inc.
C09B23/145C07D401/12C09B23/0008C09B23/0025C09B23/0058C09B23/0066C09B23/04C09B23/06C09B23/102C09B23/141G01N33/582G01N33/6845G01N2458/30G01N2800/2821G01N2800/2835
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,932,479
App. No.
14/812,171
Granted
Apr 3, 2018
Kind
B2
Abstract

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

Claims (7)

1. The dye TOL-11.

2. The dye TOL-2.

3. The dye TOL-6.

4. A kit comprising one or more dyes selected from the group consisting of TOL-11, TOL-2, and TOL-6.

5. The kit of claim 4 , further comprising a dye selected from the group consisting of S-43, S13, S-39, and S-42.

6. The kit of claim 4 , further comprising a dye selected from the group consisting of YAT-2134, YAT-2148, YAT-2149, YAT-2150, YAT-2135, YAT-2214, YAT-2213, and YAT-2324.

7. The kit of claim 4 , comprising more than one dye selected from the group consisting TOL-11, TOL-2, and TOL-6.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Jul 24, 2023
From: GEMINO HEALTHCARE FINANCE, LLC D/B/A SLR HEALTHCARE ABL
To: ENZO BIOCHEM, INC.; ENZO CLINICAL LABS, INC.; ENZO LIFE SCIENCES U.S. HOLDING CORP; ENZO LIFE SCIENCES, INC.
Reel/Frame 064369/0031 →
SECURITY INTEREST Recorded Apr 3, 2023
From: ENZO LIFE SCIENCES, INC.; ENZO CLINICAL LABS, INC.; ENZO BIOCHEM, INC.; ENZO LIFE SCIENCES U.S. HOLDING CORP
To: GEMINO HEALTHCARE FINANCE, LLC D/B/A SLR HEALTHCARE ABL
Reel/Frame 063239/0103 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2015
From: PATTON, WAYNE FORREST; YARMOLUK, SERGIY M.; PANDE, PRAVEEN; KOVALSKA, VLADYSLAVA; DAI, LIJUN; VOLKOVA, KATERYNA; COLEMAN, JACK; LOSYTSKYY, MYKHAYLO; LUDLAM, ANTHONY; BALANDA, ANATOLIY
To: ENZO BIOCHEM, INC.
Reel/Frame 036224/0787 →
Continuity (2)
Division 12592639 · Nov 30, 2009
Related Publication 20150376411A1 · Dec 31, 2015