Measuring device and methods for use therewith
View Patent ↗The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
1. An apparatus for use with a reaction cell having a first electrode and a second electrode, the apparatus comprising:
a voltage or current source providing a controllable voltage or current to the first electrode;
a voltage sensor sensing voltage provided at the first electrode;
an amplifier;
switch means switchable between first and second positions, said switch means in said first position disposing the amplifier to measure current through the second electrode, thereby measuring current through the reaction cell, said switch means in said second position disposing the amplifier to measure voltage present at the second electrode.
2. The apparatus of claim 1 , wherein the switch means comprises first, second, and third analog switches, the first analog switch connecting the second electrode and an inverting input of the amplifier, the second analog switch connecting the second electrode and a non-inverting input of the amplifier, the third analog switch connecting the non-inverting input of the amplifier and a reference voltage, the first position defined by the first and third switches being closed and the second switch being open, the second position defined by the first and third switches being open and the second switch being closed.
3. A method for use in a test equipment apparatus having an electrochemical cell disposed to receive a bodily fluid of a human user, the apparatus comprising electronic circuitry, the method comprising the steps of:
under automatic control of the electronic circuitry, allowing electrical current to flow through the cell by means of a current source or source of potential external to the cell and measuring said current;
thereafter, under automatic control of the electronic circuitry, ceasing the flow of electrical current from the current source or source of potential external to the cell; thereafter, under automatic control of the electronic circuitry, measuring an electrical potential at the cell; and
evaluating a function of the measured current and the measured electrical potential, whereby a measure of characteristic of the bodily fluid is evaluated.
4. The method of claim 3 wherein the bodily fluid is blood.
5. The method of claim 4 wherein the electrochemical cell comprises a reagent reactive with glucose, and the evaluated characteristic of the blood is a concentration of glucose in the blood.
6. The method of claim 3 wherein the bodily fluid is urine.
7. The method of claim 3 wherein the measurement of the current comprises measuring the duration of the current.
8. The method of claim 3 wherein the allowing of electrical current to flow through the cell comprises applying a constant current through the cell.
9. The method of claim 3 wherein the allowing of electrical current to flow through the cell comprises applying a time-variant voltage to the cell.
10. The method of claim 9 wherein the voltage applied to the cell comprises a sinusoidal potential.
11. The method of claim 9 wherein the voltage applied to the cell comprises a ramp potential.
12. The method of claim 3 wherein the test equipment comprises a housing and the electrochemical cell is within a test strip external to the housing, the method further comprising the steps, performed before the step of allowing of electrical current to flow through the cell, of:
inserting the test strip into a connector at the housing, and applying the bodily fluid to the electrochemical cell.
13. The method of claim 12 further comprising the step, performed after the step of measuring an electrical potential at the cell, of:
removing the test strip from the housing.
14. The method of claim 3 wherein the electrochemical cell comprises at least first and second electrodes, and wherein the step of ceasing the allowing of electrical current to flow from the current source or source of potential external to the cell further comprises: opening a first switch whereby at least the first electrode of the electrochemical cell is isolated from the current source or source of potential external to the cell.
15. The method of claim 14 wherein the step of ceasing the allowing of electrical current to flow from the current source or source of potential external to the cell further comprises:
opening a second switch whereby at least the second electrode of the electrochemical cell is isolated from the current source or source of potential external to the cell.