IP Library › Patent Application 14817827
Patent Application
App. No. 14/817,827

Pseudopolymorphic Forms Of A HIV Protease Inhibitor

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Quick Facts
Patent No.
US None
App. No.
14/817,827
Abstract

New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate and processes for producing them are disclosed.

Claims (19)

1 - 15 . (canceled)

16 . An alcohol solvate of the compound (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate.

17 . The alcohol solvate of claim 16 , wherein the alcohol is a C1-C4 alcohol.

18 . The alcohol solvate of claim 16 , wherein the alcohol is a C1 alcohol, a C3 alcohol, or a C4 alcohol.

19 . The alcohol solvate of claim 16 , wherein the alcohol is a C1 alcohol.

20 . The alcohol solvate of claim 16 , wherein the alcohol is a C3 alcohol.

21 . The alcohol solvate of claim 16 , wherein the alcohol is a C4 alcohol.

22 . A composition comprising an alcohol solvate of the compound (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate and a carrier.

23 . The composition of claim 22 , wherein the alcohol is a C1 alcohol, a C3 alcohol, or a C4 alcohol.

24 . The composition of claim 22 , wherein the alcohol is a C1 alcohol.

25 . The composition of claim 22 , wherein the alcohol is a C3 alcohol.

26 . The composition of claim 22 , wherein the alcohol is a C4 alcohol.

27 . A method of treating a mammal having an HIV infection comprising administering to the mammal, a therapeutically effective amount of an alcohol solvate of the compound (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate.

28 . The method of claim 27 , wherein the alcohol solvate is administered in an amount sufficient to reduce the viral load of the HIV, increase CD4+ cell count, or inhibit HIV protease activity.

29 . The method of claim 27 , wherein the alcohol is a C1-C4 alcohol.

30 . The method of claim 27 , wherein the alcohol is a C1 alcohol.

31 . The method of claim 27 , wherein the alcohol is a C2 alcohol.

32 . The method of claim 27 , wherein the alcohol is a C3 alcohol.

33 . The method of claim 27 , wherein the alcohol is a C4 alcohol.