Extracellular matrix constructs for treating damaged biological tissue
View Patent ↗Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
1. An extracellular matrix (ECM) construct for tissue repair, comprising:
a biodegradable and bioremodelable support scaffold; and
a biodegradable and bioremodelable microneedle anchoring member having a top and bottom surface, said microneedle anchoring member including a plurality of biodegradable microneedles that are configured to pierce tissue and anchor therein, said plurality of biodegradable microneedles projecting from at least said microneedle anchoring member top surface,
said biodegradable and bioremodelable support scaffold and anchoring member comprising acellular mesothelial tissue, wherein, when said ECM construct is in communication with host tissue, said microneedle anchoring member secures said ECM construct to said host tissue for an engagement period of time in the range of at least 1-3 months, wherein said ECM construct biodegrades and is at least partially remodeled by said host tissue.
2. The ECM construct of claim 1 , wherein said biodegradable and bioremodelable support scaffold and microneedle anchoring members comprise an integral member.
3. The ECM construct of claim 1 , wherein said acellular mesothelial tissue comprises at least one supplemental biologically active agent.
4. The ECM construct of claim 3 , wherein said supplemental biologically active agent comprises a basic fibroblast growth factor (bFGF).
5. The ECM construct of claim 1 , wherein said acellular mesothelial tissue comprises at least one pharmacological agent.
6. The ECM construct of claim 5 , wherein said pharmacological agent comprises an anti-inflammatory agent.
7. The ECM construct of claim 5 , wherein said pharmacological agent comprises an antibiotic.
8. The ECM construct of claim 5 , wherein said pharmacological agent comprises a statin.