MULTIBRANCHED BIOADHESIVE COMPOUNDS AND SYNTHETIC METHODS THEREFOR

1 .- 37 . (canceled)

38 . A bioadhesive construct, comprising: a support suitable for tissue repair or reconstruction; and

a multihydroxyphenyl (DHPD) functionalized polymer (DHPp), wherein the multihydroxyphenyl (DHPD) functionalized polymer (DHPp) is applied as a pattern, presenting coated and uncoated regions on the support.

39 . The bioadhesive construct of claim 38 , wherein the coated region provides initial bonding strength to secure in place the bioadhesive construct upon implantation, and the uncoated region provides an unobstructed path for tissue ingrowth into the support.

40 . The bioadhesive construct of claim 38 , wherein the support comprises at least one of: a natural material and man made materials.

41 . The bioadhesive construct of claim 40 , wherein the natural material is selected from the group consisting of: collagen, pericardium, dermal tissues, and small intestinal submucosa.

42 . The bioadhesive construct of claim 40 , wherein the man made material is selected from the group consisting of: polypropylene, polyethylene, polybutylene, polyesters, PTFE, PVC, polyurethanes and combinations thereof.

43 . The bioadhesive construct of claim 38 , wherein the support comprises tissue that has been cleaned and decellularized.

44 . The bioadhesive construct of claim 38 , wherein the support is a film, a mesh, a membrane, a nonwoven or a prosthetic.

45 . The bioadhesive construct of claim 38 , further comprising an oxidant.

46 . The bioadhesive construct of claim 45 , wherein the oxidant is formulated with the coating.

47 . The bioadhesive construct of claim 45 , wherein the oxidant is applied to the coating.

48 . The bioadhesive construct of claim 38 , wherein the bioadhesive comprises a compound comprising the formula (I)

wherein

each L a , L c , L e , L g and L i , independently, is a linker;

each L k and L m , independently, is a linker or a suitable linking group selected from amine, amide, ether, ester, urea, carbonate or urethane linking groups;

each X, X 3 , X 5 , X 7 , X 9 , X 11 , X 13 and X 15 , independently, is an oxygen atom or NR;

R, if present, is H or a branched or unbranched C1-10 alkyl group;

each R 1 , R 3 , R 5 , R 7 , R 9 , R 11 , R 13 and R 15 , independently, is a branched or unbranched C1-C15 alkyl group;

each DHPD xx and DHPD dd , independently, is a multihydroxy phenyl derivative residue;

ee is a value from 1 to about 80;

gg is a value from 0 to about 80:

ii is a value from 0 to about 80;

kk is a value from 0 to about 80;

mm is a value from 0 to about 80;

oo is a value from 1 to about 120;

qq is a value from 1 to about 120;

ss is a value from 1 to about 120;

uu is a value from 1 to about 120; and

vv is a value from 1 to about 80.

49 . A bioadhesive construct, comprising: a support suitable for tissue repair or reconstruction; and

a multihydroxyphenyl (DHPD) functionalized polymer (DHPp), wherein the multihydroxyphenyl (DHPD) functionalized polymer (DHPp) is applied as a pattern, presenting coated and uncoated regions on the support and providing at least two rates of cellular infiltration, wherein the DHPp coated region has a first and slower cellular infiltration rate upon implanting in a living being, and wherein the uncoated region has a second, and faster cellular infiltration rate upon implantation in a living being.

50 . The bioadhesive construct of claim 49 , wherein the support comprises at least one of: a natural material and man made materials.

51 . The bioadhesive construct of claim 50 , wherein the natural material is selected from the group consisting of: collagen, pericardium, dermal tissues, and small intestinal submucosa.

52 . The bioadhesive construct of claim 50 , wherein the man made material is selected from the group consisting of: polypropylene, polyethylene, polybutylene, polyesters, PTFE, PVC, polyurethanes and combinations thereof.

53 . The bioadhesive construct of claim 49 , wherein the support comprises tissue that has been cleaned and decellularized.

54 . The bioadhesive construct of claim 49 , wherein the support is a film, a mesh, a membrane, a nonwoven or a prosthetic.

55 . The bioadhesive construct of claim 49 , further comprising an oxidant.

56 . The bioadhesive construct of claim 55 , wherein the oxidant is formulated with the coating.

57 . The bioadhesive construct of claim 55 , wherein the oxidant is applied to the coating.

58 . The bioadhesive construct of claim 49 , wherein the bioadhesive comprises a compound comprising the formula (I)

wherein

each L a , L c , L e , L g and L i , independently, is a linker;

each L k and L m , independently, is a linker or a suitable linking group selected from amine, amide, ether, ester, urea, carbonate or urethane linking groups;

each X, X 3 , X 5 , X 7 , X 9 , X 11 , X 13 and X 15 , independently, is an oxygen atom or NR;

R, if present, is H or a branched or unbranched C1-10 alkyl group;

each R 1 , R 3 , R 5 , R 7 , R 9 , R 11 , R 13 and R 15 , independently, is a branched or unbranched C1-C15 alkyl group;

each DHPD xx and DHPD dd , independently, is a multihydroxy phenyl derivative residue;

ee is a value from 1 to about 80;

gg is a value from 0 to about 80:

ii is a value from 0 to about 80;

kk is a value from 0 to about 80;

mm is a value from 0 to about 80;

oo is a value from 1 to about 120;

qq is a value from 1 to about 120;

ss is a value from 1 to about 120;

uu is a value from 1 to about 120; and

vv is a value from 1 to about 80.