Systems and methods for minimally-invasive optical-acoustic imaging
An imaging guidewire can include one or more optical fibers communicating light along the guidewire. At or near its distal end, one or more blazed or other fiber Bragg gratings (FBGs) directs light to a photoacoustic transducer material that provides ultrasonic imaging energy. Returned ultrasound is sensed by an FBG sensor. A responsive signal is optically communicated to the proximal end of the guidewire, and processed to develop a 2D or 3D image. In one example, the guidewire outer diameter is small enough such that an intravascular catheter can be passed over the guidewire. Techniques for improving ultrasound reception include using a high compliance material, resonating the ultrasound sensing transducer, using an attenuation-reducing coating and/or thickness, and/or using optical wavelength discrimination. Techniques for improving the ultrasound generating transducer include using a blazed FBG, designing the photoacoustic material thickness to enhance optical absorption. Techniques for distinguishing plaque or vulnerable plaque may be used to enhance the displayed image.
1. A method of imaging a blood vessel of a subject comprising:
providing an elongated body sized and shaped to be inserted into the blood vessel, the elongated body having proximal and distal ends, the elongated body including a plurality of optical fibers extending lengthwise along the elongated body, each optical fiber including at least one imaging portion including an optical-to-acoustic transducer and an acoustic-to-optical transducer;
sequentially transmitting light along the plurality of optical fibers;
sequentially transducing the transmitted light into acoustic energy;
sequentially providing the acoustic energy to a region of interest in the vasculature;
sequentially receiving at the imaging portion responsive acoustic energy from the region of interest;
sequentially transducing the received acoustic energy into responsive light;
sequentially communicating the responsive light along the plurality of optical fibers; and
forming a viewable image of at least a portion of the region of interest based at least in part on the responsive light.
2. The method of claim 1 , in which the forming a viewable image of at least a portion of the region of interest includes forming an image from a plurality of the acoustic-to-optical transducers.
3. The method of claim 1 , comprising:
sequentially accessing selected optical fibers.
4. The method of claim 1 , wherein the at least one imaging portion includes at least two imaging portions per each of the plurality of optical fibers, and in which the forming a viewable image of at least a portion of the region of interest includes forming a three-dimensional image of the region of interest.
5. The method of claim 4 , in which the forming a viewable image of at least a portion of the region of interest includes:
sequentially accessing selected optical fibers; and
sequentially accessing selected imaging portions.
6. The method of claim 5 , wherein sequentially accessing selected imaging portions includes selectively individually addressing the different imaging portions.
7. The method of claim 6 , selectively individually addressing the different imaging portions includes individually addressing the different imaging portions using different wavelengths of light.
8. The method of claim 1 , wherein sequentially transmitting light along the plurality of optical fibers includes sequentially transmitting a first optical signal along the plurality of optical fibers, and wherein sequentially communicating the responsive light along the plurality of optical fibers includes sequentially providing responsive modulation of a second optical signal.
9. The method of claim 1 , comprising:
identifying a plaque deposit,
wherein forming a viewable image of at least a portion of the region of interest includes providing a distinctive display of the plaque deposit.
10. The method of claim 1 , comprising:
inserting a guidewire including the elongated body into the blood vessel of the subject.