SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
1 . (canceled)
2 . A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:
wherein:
B 1 is
R 1 is methyl or ethynyl;
R 2 is hydroxyl;
R 3 is hydroxyl;
R 4 is
R 5A is O − or OH;
R 5B is
where n is 0 or 1;
R 6A is unsubstituted C 1-6 alkyl;
R 9 , R 10 and R 11 are independently absent or hydrogen; and
Z 1 is O or S.
3 . The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is S.
4 . The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein B 1 is
5 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 6A is methyl.
6 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl.
7 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 1 is ethynyl.
8 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein n is 1.
9 . The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is O.
10 . The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein B 1 is
11 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl.
12 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein R 1 is ethynyl.
13 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein n is 1.