Plasma generation with dialysis systems
Embodiments for a blood plasma and red blood cell generation device are disclosed. The device may operate as an alternative modality of the dialysis machine, as part of the dialysis machine and/or as an add-on module. The fluid handling components of the plasma generation system may be integrated with a microprocessor unit for controlling and executing generation of plasma, or a control unit of the dialysis machine may be adapted to control the plasma generation aspects of the treatment.
1. A blood processing device, comprising:
an extracorporeal circuit having:
at least a first dialyzer and a second dialyzer, wherein the first dialyzer has fibers with a first pore size, and wherein the second dialyzer is located downstream of a dialysate outlet port of the first dialyzer and has fibers with a second pore size that is smaller than the first pore size;
a first restriction valve located downstream of the dialysate outlet port of the first dialyzer and upstream of the second dialyzer; and
a second restriction valve located downstream of a blood outlet port of the first dialyzer,
wherein the first restriction valve and the second restriction valve are configured to maintain a flow rate of plasma and dialysate from the dialysate outlet port of the first dialyzer below a threshold, wherein the second restriction valve is configured to control a flow rate of blood at the blood outlet port of the first dialyzer to be less than a flow rate of whole blood entering a blood inlet port of the first dialyzer, and wherein restriction action of the second restriction valve is controlled to ensure at least a minimum flow rate of plasma and dialysate is maintained from the dialysate outlet port of the first dialyzer.
2. The blood processing device according to claim 1 , wherein the second dialyzer is a standard dialyzer having fibers with a pore size characterized by a molecular weight cut off around 60,000 daltons, and wherein the first dialyzer is a plasma dialyzer having fibers with a pore size characterized by a molecular weight cut off greater than 60,000 daltons.
3. The blood processing device according to claim 1 , further comprising:
a control unit that controls fluid flow rates among components of the extracorporeal circuit.
4. The blood processing device according to claim 3 , wherein the control unit further controls modality of the device to collect blood plasma and/or red-blood cells.
5. The blood processing device according to claim 1 , wherein the first dialyzer and the second dialyzer each include a semipermeable membrane, and wherein blood plasma produced by the first dialyzer is directed to an inlet port of the second dialyzer located downstream of the first dialyzer.
6. The blood processing device according to claim 1 , further comprising:
a plasma bag, wherein plasma exiting the second dialyzer may enter into the plasma bag for collection.
7. The blood processing device according to claim 1 , further comprising:
a recirculation loop that connects the extracorporeal circuit directly after the second dialyzer to the extracorporeal circuit directly before the second dialyzer.
8. The blood processing device according to claim 7 , wherein blood plasma in the recirculation loop is repeatedly cycled through the second dialyzer.
9. The blood processing device according to claim 1 , further comprising:
a third dialyzer arranged in parallel with the first dialyzer and/or the second dialyzer.
10. The blood processing device according to claim 9 , wherein the third dialyzer is a standard dialyzer that allows for concurrent hemodialysis, while the first dialyzer and the second dialyzer allow for plasma filtration and/or plasmadiafiltration.
11. The blood processing device according to claim 1 , further comprising:
an adsorbent cartridge disposed downstream of the first dialyzer.
12. The blood processing device according to claim 11 , wherein the adsorbent cartridge is disposed upstream of the second dialyzer to reduce the concentrate of specific plasma constituents before entering the second dialyzer.
13. The blood processing device according to claim 11 , wherein the adsorbent cartridge is disposed downstream of the second dialyzer such that the flow rate of the blood plasma in the extracorporeal circuit between the first dialyzer and second dialyzer is not rate-limited by the output of the adsorbent cartridge.
14. A dialysis system, comprising:
an extracorporeal circuit having:
at least a first dialyzer and a second dialyzer, wherein the first dialyzer has fibers with a first pore size, and wherein the second dialyzer is located downstream of a dialysate outlet port of the first dialyzer and has fibers with a second pore size that is smaller than the first pore size;
a first restriction valve located downstream of the dialysate outlet port of the first dialyzer and upstream of the second dialyzer; and
a second restriction valve located downstream of a blood outlet port of the first dialyzer,
wherein the first restriction valve and the second restriction valve are configured to maintain a flow rate of plasma and dialysate from the dialysate outlet port of the first dialyzer below a threshold, wherein the second restriction valve is configured to control a flow rate of blood at the blood outlet port of the first dialyzer to be less than a flow rate of whole blood entering a blood inlet port of the first dialyzer, and wherein restriction action of the second restriction valve is controlled to ensure at least a minimum flow rate of plasma and dialysate is maintained from the dialysate outlet port of the first dialyzer;
a dialysis machine that is fluidly coupled to the first dialyzer and/or the second dialyzer; and
a control unit to control fluid flow rates.
15. The dialysis system according to claim 14 , wherein the first dialyzer and the second dialyzer each include a semipermeable membrane, and wherein blood plasma produced by the first dialyzer is directed to an inlet port of the second dialyzer located downstream of the first dialyzer.
16. The dialysis system according to claim 14 , further comprising:
a plasma bag, wherein plasma exiting the second dialyzer may enter into the plasma bag for collection.
17. The dialysis system according to claim 14 , further comprising:
a recirculation loop that connects the extracorporeal circuit directly after the second dialyzer to the extracorporeal circuit directly before the second dialyzer.
18. The dialysis system according to claim 14 , further comprising:
a third dialyzer arranged in parallel with the first dialyzer and/or the second dialyzer.
19. The dialysis system according to claim 14 , further comprising:
an adsorbent cartridge disposed downstream of the first dialyzer.