Methods for treatment of diseases
View Patent ↗The present disclosure relates to methods of treating a range of diseases or conditions. The methods involve administration of a superoxide dismutase mimetic.
1. A method of treating an inflammatory disease or condition selected from the group consisting of pancreatitis, colitis, inflammatory bowel disease, rheumatoid arthritis, chronic obstructive pulmonary disorder (COPD) and asthma in a human patient, the method comprising administering to the patient 25 mg to 450 mg of a superoxide dismutase mimetic at a rate of at least 100 mg/hr, wherein the superoxide dismutase mimetic corresponds to Formula (GC4419):
and X and Y are independently halo ligands.
2. The method of claim 1 , wherein the superoxide dismutase mimetic is administered in a dosage unit formulation comprising at least 50 mg of the superoxide dismutase mimetic in a container.
3. The method of claim 1 , wherein the superoxide dismutase mimetic is dissolved in a solution comprising about 0.25 mg/mL to about 3.5 mg/mL superoxide dismutase mimetic and contained in an IV bag.
4. The method of claim 1 , wherein X and Y are independently selected from monodentate ligands.
5. The method of claim 1 , wherein the method provides an exposure as measured by an area under the curve (AUC) of at least 4,000 ng-h/mL as calculated from the measurement of the superoxide dismutase mimetic concentration in the patient's plasma.
6. The method of claim 1 , wherein the superoxide dismutase mimetic is administered intravenously.
7. The method of claim 1 , wherein the inflammatory disease or condition is selected from the group consisting of asthma and colitis.