IP Library › Patent Application 14838206
Patent Application
App. No. 14/838,206

Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease

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Quick Facts
Patent No.
US None
App. No.
14/838,206
Abstract

The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.

Claims (7)

1 - 26 . (canceled)

27 . A method of effecting prophylaxis or treating a disease characterized by Lewy bodies or alpha-synuclein aggregation in the brain, the method comprising administering to a patient having or at risk of the disease an effective regime of an agent that induces an antibody that specifically binds to an epitope within residues 110-130 of human alpha-synuclein, residues being numbered according to SEQ ID NO:1.

28 . The method of claim 27 , wherein the agent is a fragment of alpha-synuclein.

29 . The method of claim 28 , wherein the fragment has no more than 30 contiguous residues total of alpha-synuclein.

30 . The method of claim 28 , wherein the fragment induces an antibody to an eptiope within residues 118-126 of alpha-synuclein.

31 . The method of claim 30 , wherein the fragment comprises residues 118-126 of alpha synuclein.

32 . The method of any of claims 27 - 31 , wherein the fragment is linked to a carrier.