Antimicrobial Amorphous Compositions
The present invention comprises compositions and methods for providing antimicrobial compositions. The antimicrobial compositions comprise gel delivery vehicles comprising stabilized silver, wherein ionic silver is provided to a site for antimicrobial purposes. Methods of making and using such compositions are taught, including application of the silver-containing gel compositions to wounds, burns, abrasions, cuts, surgical incision, sites where skin or organ integrity has been breached, and other sites to supply an antimicrobial environment.
1 - 27 . (canceled)
28 . An antimicrobial composition comprising an amorphous delivery vehicle and a stabilized silver salt comprising silver ions and halide anions, wherein the stabilized silver salt is stabilized by a molar excess of halide anions to silver ions, wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure.
29 . The composition of claim 28 , wherein the halide anions comprise chloride anions.
30 . The composition of claim 28 , wherein the stabilized silver salt comprises silver chloride.
31 . The composition of claim 28 , wherein the stabilized silver salt is formed by combining silver nitrate and sodium chloride.
32 . The composition of claim 28 , wherein the ratio of the molar excess of halide anions to silver ions ranges from 1.1:1 to 200:1.
33 . The composition of claim 28 , further comprising glycerol.
34 . The composition of claim 28 , further comprising a polymer matrix powder.
35 . The composition of claim 34 , wherein the polymer matrix powder comprises polyacrylamide.
36 . The composition of claim 28 , further comprising water.
37 . The composition of claim 28 , further comprising an active agent.
38 . The composition of claim 37 , wherein the active agent is an antimicrobial agent, an antifungal agent, an antibacterial agent, an antiviral agent, an anti-parasitic agent, a wound healing agent, or a combination thereof.
39 . The composition of claim 28 , wherein the delivery vehicle comprises a polymeric composition comprising an aqueous composition of an alkylcellulose derivative, sodium carboxycellulose, carboxymethylcellulose, hydroxyethylcellulose, or hydroxypropyl cellulose.
40 . The composition of claim 28 , wherein the delivery vehicle is present in an amount greater than 5 wt. % based on the total weight of the composition.
41 . The composition of claim 28 , wherein the delivery vehicle comprises a water-in-oil or oil-in-water emulsion.
42 . The composition of claim 28 , wherein the delivery vehicle comprises a hydrogel, a gel, a jelly, a lotion, an ointment, an emulsion, or a cream.
43 . The composition of claim 28 , further comprising an electron acceptor.
44 . The composition of claim 43 , wherein the electron acceptor comprises cupric chloride, ferric chloride, zinc chloride, gold, platinum, or cesium.
45 . The composition of claim 28 , further comprising an oxidizing agent.
46 . The composition of claim 45 , wherein the oxidizing agent comprises hydrogen peroxide or zinc peroxide.
47 . An antimicrobial composition comprising an amorphous delivery vehicle comprising a polymeric composition comprising an aqueous composition of an alkylcellulose derivative, sodium carboxycellulose, carboxymethylcellulose, hydroxyethylcellulose, or hydroxypropyl cellulose; a stabilized silver salt formed by combining silver nitrate with a molar excess of sodium chloride to provide a ratio of excess of halide anions to silver ions ranges from 1.1:1 to 200:1; glycerol; and an electron acceptor comprising cupric chloride, ferric chloride, zinc chloride, gold, platinum, or cesium, wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure.
48 . The composition of claim 47 , further comprising a polymer matrix powder comprising polyacrylamide.