Low oxygen in vivo analyte sensor
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
1. A transcutaneous continuous sensor device for measuring a concentration of glucose in a biological fluid of a host, the device comprising:
a glucose sensor comprising an electrode and a membrane comprising a first domain and a second domain, wherein the first domain comprises an enzyme configured to react with glucose, wherein the second domain comprises polyurethaneurea;
wherein the glucose sensor is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.6 mg/L.
2. The device of claim 1 , wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.4 mg/L.
3. The device of claim 1 , wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.15 mg/L.
4. The device of claim 1 , wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.1 mg/L.
5. The device of claim 1 , wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.05 mg/L.
6. The device of claim 1 , wherein the glucose sensor is further configured to measure glucose concentration with substantial linearity at glucose concentrations of up to 400 mg/dL at an oxygen concentration of 0.02 mg/L.
7. The device of claim 1 , wherein the device is configured to have an operable life implanted within a host of at least about one week.
8. The device of claim 1 , further comprising sensor electronics operably connected to the electrode, wherein the sensor electronics is configured to measure a current produced by the electrode.