Use of melanocortins to treat insulin sensitivity
View Patent ↗The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.
1. A method of treating insulin resistance in a subject in need thereof, comprising peripheral administration of an effective amount of Hydantoin(C(O)-(Arg-Gly))-c(Cys-Glu-His-D-Phe-Arg-Trp-Cys)-NH 2 (SEQ ID NO:278) or a pharmaceutically acceptable salt thereof to treat said insulin resistance in said subject.
2. The method according to claim 1 , wherein said subject is obese or overweight.
3. The method according to claim 1 , wherein said subject is normal weight or lean.
4. The method according to claim 1 , wherein said peripheral administration is oral, subcutaneous, intraperitoneal, intramuscular, intravenous, rectal, transdermal or intranasal.
5. The method according to claim 4 , wherein said administration is continuous, hourly, four times daily, three time daily, twice daily, once daily, once every other day, twice weekly, once weekly, once every two weeks, once a month, or once every two months.
6. The method according to claim 5 , wherein said administration is once daily.
7. The method according to claim 5 , wherein said administration is once every other day.
8. The method according to claim 5 , wherein said administration is once weekly.
9. The method according to claim 1 , wherein said subject is non-diabetic.
10. The method according to claim 1 , wherein said subject suffers from Type II diabetes.
11. The method according to claim 1 , wherein said method reduces the body weight of said subject in need thereof.
12. The method according to claim 11 , wherein said subject is obese or overweight.
13. The method according to claim 11 , wherein said peripheral administration is oral, subcutaneous, intraperitoneal, intramuscular, intravenous, rectal, transdermal or intranasal.
14. The method according to claim 13 , wherein said administration is continuous, hourly, four times daily, three time daily, twice daily, once daily, once every other day, twice weekly, once weekly, once every two weeks, once a month, or once every two months.
15. The method according to claim 14 , wherein said administration is once daily.
16. The method according to claim 14 , wherein said administration is once every other day.
17. The method according to claim 14 , wherein said administration is once weekly.