Portable, nitric oxide generator
An apparatus for portable delivery of nitric oxide without the need for pressurized tanks, power supplies, or other devices provides a single therapy session by triggering a heater to heat a reaction chamber. A piercing assembly may trigger to open sealed containers, such as bags, of liquid water or salt water in order to activate the heaters. Upon addition of liquid such as water or salt water to a chemically reactive heating element, heat is generated to activate the chemicals generating nitric oxide within a sealed reactor. Upon triggering, liquid containers are unsealed, the liquid drains down to initiate reaction of the heating chemicals, and the heat begins to penetrate the reactor. The reactor, in turn, heats its contents, which react to form nitric oxide expelled by the reactor to a line feeding a cannula for therapy.
1. A method of generating nitric oxide, the method comprising:
providing a mixture of reactants comprising a nitrate compound and a nitrite compound in a reactor;
providing a heating system comprising water in a sealed, rupturable container and water-activated chemicals positioned below the mixture of reactants to heat the reactor;
rupturing the container in a manner that activates the water-activated chemicals and produces heat;
heating the reactor, thereby generating nitric oxide gas;
delivering the nitric oxide gas at substantially ambient conditions to a user to provide a therapeutically safe concentration of the nitric oxide gas.
2. The method of claim 1 , wherein the mixture of reactants is configured as granules.
3. The method of claim 2 , further comprising sizing the granules to melt and react without vaporizing at least one of the reactants in the mixture.
4. The method of claim 1 , further comprising controlling the heating system to control a rate of generation of the nitric oxide gas.
5. The method of claim 1 , wherein the reactants consist essentially of:
a non-deliquescent nitrite compound;
a nitrate compound; and
a metal oxide.
6. The method of claim 5 , wherein the non-deliquescent nitrite compound is sodium nitrite, the nitrate compound is potassium nitrate, and the metal oxide is chromic oxide.
7. The method of claim 1 , wherein the water in the heating system is salt water.
8. A method of providing nitric oxide comprising:
selecting a generator comprising a reactor system, self-contained and containing first reactants and second reactants;
generating heat by activating the second reactants;
generating nitric oxide by activating the first reactants in response to the generating heat; and
delivering a therapeutically effective amount of the nitric oxide.
9. The method of claim 8 , wherein the nitric oxide is at a concentration of from about a hundred parts per million to about five thousand parts per million in the breathing air.
10. The method of claim 8 , wherein the breathing air is delivered to a subject through nasal inhalation to provide approximately five thousand parts per million of nitric oxide to the subject.
11. The method of claim 8 , further comprising combining a constituent of the first reactants in a dry granular state with the other first reactants before activating the first reactants.
12. The method of claim 11 , wherein the constituent includes at least one selected from the group consisting of potassium nitrite and sodium nitrite.
13. The method of claim 8 , wherein selecting the generator further comprises:
providing a first container to contain a liquid and insulate space interior to the first container;
positioning a first chemical reactor in the first container to contain a first reaction; and
positioning a second chemical reactor in the first container and below the first reactor to contain a second reaction heating the first reactor.
14. The method of claim 8 , further comprising cooling the nitric oxide after generating nitric oxide.