Drug loaded microspheres for post-operative chronic pain
A microsphere is claimed which includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.
1. A method for treating chronic pain comprising:
implanting at least one microsphere at a treatment site, the microsphere comprising:
at least one local anesthetic and poly(lactic-co-glycolic acid) including polylactic acid and glycolic acid at a ratio of about 75:25;
wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours; and
relieving chronic pain for at least 28 days.
2. The method according to claim 1 , wherein the at least one microsphere is implanted preoperatively.
3. The method according to claim 1 , wherein the at least one microsphere is implanted postoperatively.
4. The method according to claim 1 , further comprising forming a suspension including the at least one microsphere.
5. The method according to claim 4 , further comprising injecting the suspension into the treatment site.
6. The method according to claim 4 , further comprising depositing the suspension on at least a portion of a medical device to form a film thereon, the film including the at least one microsphere particle.
7. The method according to claim 1 , wherein the at least one local anesthetic is bupivacaine.
8. The method according to claim 1 , wherein the at least one local anesthetic is present in amount of about 60% by weight of the at least one microsphere.
9. The method according to claim 1 , wherein implanting at least one microsphere at a treatment site includes implanting at least one microsphere wherein the at least one local anesthetic and the poly(lactic-co-glycolic acid) are uniformly distributed throughout the at least one microsphere.
10. The method according to claim 1 , wherein implanting at least one microsphere at a treatment site includes implanting at least one microsphere wherein the at least one microsphere is porous with pores being from about 0.1% to about 15% by volume of the at least one microsphere.
11. The method according to claim 1 , wherein the treatment site is a surgical site of at least one of herniorraphy, thoracotomy, or joint arthroscopy.
12. A method for treating chronic pain comprising:
implanting at least one microsphere at a surgical site of at least one of herniorraphy, thoracotomy, or joint arthroscopy, the microsphere comprising:
at least one local anesthetic and poly(lactic-co-glycolic acid) including polylactic acid and glycolic acid at a ratio of about 75:25;
wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours; and
reducing chronic pain associated with at least one of herniorraphy, thoracotomy, or joint arthroscopy for at least 28 days.
13. The method according to claim 12 , wherein the at least one microsphere is implanted preoperatively.
14. The method according to claim 12 , wherein implanting at least one microsphere at a treatment site includes implanting at least one microsphere wherein the at least one local anesthetic and the poly(lactic-co-glycolic acid) are uniformly distributed throughout the at least one microsphere.
15. The method according to claim 12 , wherein implanting at least one microsphere at a treatment site includes implanting at least one microsphere wherein the at least one microsphere is porous with pores being from about 0.1% to about 15% by volume of the at least one microsphere.