Compositions and methods for stimulation MAGP-1 to improve the appearance of skin
View Patent ↗The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
1. A method for improving the condition or aesthetic appearance of human skin comprising topically applying to skin in need thereof an effective amount of a composition comprising:
(i) a MAGP-1 active agent is
an ethanolic extract of Antidesma bunius , and
(ii) a cosmetically acceptable vehicle,
wherein said improvement is selected from the group consisting of:
(a) treatment, reduction, and/or prevention of fine lines or wrinkles,
(b) reduction of skin pore size,
(c) improvement in skin thickness, plumpness, and/or firmness;
(d) improvement in skin suppleness and/or softness;
(e) improvement in skin tone, radiance, and/or clarity;
(f) improvement in procollagen and/or collagen production;
(g) improvement in maintenance and remodeling of elastin;
(h) improvement in skin texture and/or promotion of retexturization;
(i) improvement in skin barrier repair and/or function;
(j) improvement in appearance of skin contours;
(k) restoration of skin luster and/or brightness;
(l) replenishment of essential nutrients and/or constituents in the skin;
(m) improvement of skin appearance decreased by menopause;
(n) improvement in skin moisturization;
(o) increase in skin elasticity and/or resiliency;
(p) treatment, reduction, and/or prevention of skin sagging; and
(q) reduction of pigment spots; or any combination thereof.
2. The method according to claim 1 , wherein said improvement is the treatment, reduction, and/or prevention of fine lines or wrinkles.
3. The method according to claim 1 , wherein said improvement is an increase in skin elasticity and/or resiliency.
4. The method according to claim 1 , wherein said improvement is the treatment, reduction, and/or prevention of skin sagging.
5. The method according to claim 1 , wherein the composition is topically applied at least once daily for at least one week.