IP Library › Granted Patent US 9,775,860
Granted Patent B2
US 9,775,860 · App. 14/849,424 · Granted Oct 3, 2017

Prebiotic formulations and methods of use

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Quick Facts
Patent No.
US 9,775,860
App. No.
14/849,424
Granted
Oct 3, 2017
Kind
B2
Abstract

The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a prebiotic composition, optionally in combination with effective amount of a probiotic microbe or microbes.

Claims (42)

1. A method of improving a subject's gastrointestinal health comprising treating heartburn, stomach upset, bloating, diarrhea, constipation, or gas by administering a composition to a subject, wherein the composition comprises a prebiotic composition and an excipient, wherein the prebiotic composition comprises 95% or more galactooligosaccharides (GOS) by weight and less than 5% digestible saccharides by weight, wherein the GOS comprises at least 45% by weight trisaccharides.

2. The method of claim 1 , wherein the digestible saccharides comprise lactose, galactose, or glucose.

3. The method of claim 1 , wherein the prebiotic composition comprises from about 0.001 to about 1% glucose by weight.

4. The method of claim 1 , wherein the prebiotic composition comprises from about 0.01 to about 0.1% glucose by weight.

5. The method of claim 1 , wherein the prebiotic composition comprises from about 0.1% galactose to about 2% galactose by weight.

6. The method of claim 1 , wherein the prebiotic composition comprises less than 2% lactose by weight.

7. The method of claim 1 , wherein the composition is administered once or twice a day.

8. The method of claim 1 , wherein the composition does not comprise a probiotic.

9. The method of claims 1 , wherein administering comprises oral administration.

10. The method of claim 1 , wherein the composition is administered for 3 days or more.

11. The method of claim 1 , wherein the composition is administered for 7 days or more.

12. The method of claim 1 , wherein the composition is administered from 5-35 days.

13. The method of claim 1 , wherein the composition is administered on a continuous daily basis.

14. The method of claim 1 , wherein the subject is a human.

15. The method of claim 1 , wherein the subject is a non-human animal.

16. The method of claim 1 , wherein the subject is an infant up to one year of age.

17. The method of claim 1 , wherein the subject is a young child from 1 yr to 12 yrs old.

18. The method of claim 1 , wherein the subject is a teenager from 13-19 yrs old.

19. The method of claim 1 , wherein the subject is an adult from 20-64 yrs old.

20. The method of claim 1 , wherein the subject is a pregnant woman.

21. The method of claim 1 , wherein the subject is an elderly adult from 65 yrs or older.

22. The method of claim 1 , wherein the subject has diabetes.

23. A method of improving a subject's gastrointestinal health comprising treating heartburn, stomach upset, bloating, diarrhea, constipation, or gas by administering a powder composition to a subject, wherein the composition comprises a prebiotic composition and an excipient, wherein the prebiotic composition comprises 95% or more galactooligosaccharides (GOS) by weight and less than 5% digestible saccharides by weight, wherein the GOS comprises at least 45% by weight trisaccharides.

24. A method of promoting the growth of Bifidobacteria or Lactobacillus in order to improve a subject's gastrointestinal health comprising administering a composition to a subject, wherein the composition comprises a prebiotic composition and an excipient, wherein the prebiotic composition comprises 95% or more galactooligosaccharides (GOS) by weight and less than 5% digestible saccharides by weight, wherein the GOS comprises at least 45% by weight trisaccharides.

25. The method of claim 23 , wherein the digestible saccharides comprise lactose, galactose, or glucose.

26. The method of claim 23 , wherein the prebiotic composition comprises from about 0.001 to about 1% glucose by weight.

27. The method of claim 23 , wherein the prebiotic composition comprises from about 0.01 to about 0.1% glucose by weight.

28. The method of claim 23 , wherein the prebiotic composition comprises from about 0.1% galactose to about 2% galactose by weight.

29. The method of claim 23 , wherein the prebiotic composition comprises less than 2% lactose by weight.

30. The method of claim 23 , wherein the composition does not promote the growth of E. coli.

31. The method of claim 23 , wherein the composition does not comprise a probiotic.

32. The method of claim 23 , wherein the composition does not increase the growth of harmful bacteria or undesirable microbes.

33. A method of promoting the growth of lactose fermenting commensal microbes in the human gastrointestinal tract in order to improve a subject's gastrointestinal health, the method comprising administering a composition to a subject, wherein the composition comprises a prebiotic composition and an excipient, wherein the prebiotic composition comprises 95% or more galactooligosaccharides (GOS) by weight and less than 5% digestible saccharides by weight, wherein the GOS comprises at least 45% by weight trisaccharides.

34. A method of promoting the growth of lactose fermenting commensal microbes in the human gastrointestinal tract in order to improve a subject's gastrointestinal health, the method comprising administering a composition to a subject, wherein the composition comprises a prebiotic composition and an excipient, wherein the prebiotic composition comprises 80% or more galactooligosaccharides (GOS) by weight and less than 5% digestible saccharides by weight, wherein the GOS comprises 1-10% by weight pentasaccharides and at least 45% trisaccharides.

35. The method of claim 33 , wherein the digestible saccharides comprise lactose, galactose, or glucose.

36. The method of claim 33 , wherein the prebiotic composition comprises from about 0.001 to about 1% glucose by weight.

37. The method of claim 33 , wherein the prebiotic composition comprises from about 0.01 to about 0.1% glucose by weight.

38. The method of claim 33 , wherein the prebiotic composition comprises from about 0.1% galactose to about 2% galactose by weight.

39. The method of claim 33 , wherein the prebiotic composition comprises less than 2% lactose by weight.

40. The method of claim 33 , wherein the composition does not promote the growth of E. coli.

41. The method of claim 33 , wherein the composition does not comprise a probiotic.

42. The method of claim 33 , wherein the composition does not increase the growth of harmful bacteria or undesirable microbes.