Process for preparing hernia mesh from monofilament
The present invention relates to a monofilament with a segmented pie structure formed by conjugated spinning of degradable polymers and non-degradable polymers, a hernia mesh having improved flexibility and biocompatibility, and a preparation method of the monofilament. More specifically, the hernia mesh of the present invention having improved flexibility and biocompatibility is prepared using the monofilament obtained by conjugated spinning of degradable polymers and non-degradable polymers into a segmented pie form, to control it to be gradually degraded in the body, whereby the stiffness of the early stage is removed, and thereby the foreign body sensation is also removed.
1. A method of preparing a hernia mesh, comprising the steps of spinning, solidification, crystallization, and drawing to prepare a monofilament, and the steps of warping, knitting, and curing to prepare the hernia mesh, wherein:
the spinning step is performed by melting 30 to 70 vol % of a degradable polymer and 30 to 70 vol % of a non-degradable polymer, and conducting conjugated spinning to form a segmented pie structure;
the drawing step is performed by applying stress-relaxation to prepare the monofilament; and
the curing step is performed at 90 to 160° C. for 1 to 30 minutes, and
wherein the melt index of the degradable polymer is not lower than the melt index of the non-degradable polymer, and
the difference between the melt indexes of the degradable polymer and the non-degradable polymer is 10 or less,
wherein the non-degradable polymer is partitioned by the degradable polymer and the degradable polymer has a continuous form.
2. The method according to claim 1 , wherein stress-relaxation of at least 10% is applied.
3. The method according to claim 1 , wherein the degradable polymer is a homopolymer or copolymer comprising one or more monomers selected from the group consisting of glycolide, glycolic acid, lactide, lactic acid, caprolactone (ε-caprolactone), dioxanone (p-dioxanone), trimethylene carbonate, polyanhydride, and polyhydroxyalkanoate (PHA).
4. The method according to claim 3 , wherein the degradable polymer is a glycolide/caprolactone copolymer or a dioxanone trimethylenecarbonate/caprolactone copolymer.
5. The method according to claim 1 , wherein the non-degradable polymer is selected from the group consisting of polyolefins, polyamides, polyurethanes, and fluoropolymers.
6. The method according to claim 5 , wherein the non-degradable polymer is polypropylene, or a copolymer of propylene and ethylene.
7. The method according to claim 1 , wherein the non-degradable polymer is divided into at least four strands.
8. The method according to claim 1 , wherein the diameter of the monofilament is 100 to 250 μm.
9. The method according to claim 1 , wherein the stiffness of the degradable polymer after degradation is decreased at least 70% compared with that before degradation.
10. The method according to claim 1 , wherein the structure of the mesh is a square, hexagonal, or network structure.
11. The method according to claim 1 , wherein the mesh has a pore size of 0.1 to 4.0 mm and a thickness of 200 to 800 μm.
12. The method according to claim 1 , wherein the mesh has a density of 8 to 20 gauges/inch based on the distance between the needles in a warp knitting machine.
13. The method according to claim 1 , wherein the degradable polymer is partially dyed.