Dihydroquinoline-2-one derivatives

1. A Compound of formula (I)

wherein

R 1 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 2 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 3 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 4 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

or R 3 and R 4 together with the carbon atoms to which they are attached form a double bond;

R 5 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 6 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 7 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

or R 6 and R 7 together with the carbon atom to which they are attached form a cycloalkyl;

A is —C(O)NR 8 —, —S—, —O—;

R 8 is H, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 9 is a substituted aryl or substituted heteroaryl, wherein substituted aryl and substituted heteroaryl are substituted with one to three substitutents independently selected from H, halogen, oxo, cyano, alkyl, haloalkyl, cycloalkyl and halocycloalkyl;

R 10 is H, halogen, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

R 11 is H, halogen, alkyl, haloalkyl, cycloalkyl or halocycloalkyl;

or pharmaceutically acceptable salts or esters.

2. The compound of claim 1 , wherein R 1 is alkyl.

3. The compound of claim 1 , wherein R 2 is H.

4. The compound of claim 1 , wherein R 3 is H.

5. The compound of claim 1 , wherein R 4 is H.

6. The compound of claim 1 , wherein R 5 is H.

7. The compound of claim 1 , wherein R 6 is H.

8. The compound of claim 1 , wherein R 7 is H.

9. The compound of claim 1 , wherein R 8 is H.

10. The compound of claim 1 , wherein A is —O—.

11. The compound of claim 1 , wherein R 9 is substituted pyridinyl, substituted pyrimidinyl or substituted benzooxazolyl, wherein substituted pyridinyl, substituted pyrimidinyl and substituted benzooxazolyl are substituted with one to three substitutents independently selected from H, halogen, cyano, alkyl and haloalkyl.

12. The compound of claim 1 , wherein R 9 is pyridinyl, substituted pyridinyl, pyrimidinyl, substituted pyrimidinyl or benzooxazolyl, wherein substituted pyridinyl and substituted pyrimidinyl are substituted with one to three substitutents independently selected from halogen, cyano, alkyl and haloalkyl.

13. The compound of claim 1 , wherein R 9 is pyridinyl, substituted pyridinyl, pyrimidinyl, substituted pyrimidinyl or benzooxazolyl, wherein substituted pyridinyl and substituted pyrimidinyl are substituted with one to three substitutents independently selected from halogen, cyano, alkyl and haloalkyl.

14. The compound of claim 1 , wherein R 9 is pyridinyl substituted with one to three substitutents independently selected from halogen and alkyl.

15. The compound of claim 1 , wherein R 9 is methylpyridinyl, chloropyridinyl or fluoropyridinyl.

16. The compound of claim 1 , wherein R 9 is methyl, chloropyridinyl or fluoropyridinyl.

17. The compound of claim 1 , wherein R 10 is H or alkyl.

18. The compound of claim 1 , wherein R 10 is alkyl.

19. The compound of claim 1 , wherein R 11 is H or halogen.

20. The compound of claim 1 , wherein R 11 is halogen.

21. The compound of claim 1 , selected from

6-[5-(6-Chloro-pyridin-2-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

6-[5-(5-Fluoro-pyridin-2-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(6-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(4-methyl-6-trifluoromethyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(4-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(5-Chloro-pyridin-2-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(3-trifluoromethyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6[5-(2-methyl-pyrimidin-4-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6[5-(2-trifluoromethyl-pyrimidin-4-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(2-Chloro-pyrimidin-5-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6[5-(pyrimidin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(Benzooxazol-2-ylsulfanylmethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6[5-(6-methyl-pyridin-2-ylsulfanylmethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

1-Methyl-6-[5-(3-trifluoromethyl-pyridin-2-ylsulfanylmethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(3-Chloro-pyridin-2-ylsulfanylmethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethoxy]-isonicotinonitrile;

6-[5-(6-Fluoro-pyridin-2-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-6-[5-(3-fluoro-pyridin-2-yloxymethyl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

6-[5-(5-Chloro-pyridin-2-yloxymethyl)-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one;

6-[5-(6-Chloro-pyridin-2-yloxymethyl)-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-1-methyl-6-[5-(6-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-1-methyl-6-[5-(4-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-1-methyl-6-[4-methyl-5-(6-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(6-Chloro-pyridin-2-yloxymethyl)-4-methyl-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-6-[5-(3-fluoro-pyridin-2-yloxymethyl)-4-methyl-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-6-[5-(6-fluoro-pyridin-2-yloxymethyl)-4-methyl-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

2-[5-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yl]-N-(6-methyl-pyridin-2-yl)-acetamide;

N-(3-Chloro-phenyl)-2-[5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yl]-acetamide;

N-(6-Chloro-pyridin-2-yl)-2-[5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yl]-acetamide;

and pharmaceutically acceptable salts thereof.

22. The compound of claim 1 , selected from

7-Fluoro-1-methyl-6-[5-(6-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-1-methyl-6-[4-methyl-5-(6-methyl-pyridin-2-yloxymethyl)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one;

6-[5-(6-Chloro-pyridin-2-yloxymethyl)-4-methyl-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one;

7-Fluoro-6-[5-(3-fluoro-pyridin-2-yloxymethyl)-4-methyl-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one;

and pharmaceutically acceptable salts thereof.

23. A process to prepare a compound of formula (I) according to claim 1 , comprising the reaction of a compound of formula (II) in the presence of a compound of formula (III);

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , R 11 and A are as defined above, R 101 and R 102 are independently selected from alkyl and cycloalkyl, or R 101 and R 102 together with the boron atom to which they are attached form a borolane and X is halogen or triflate.

24. A pharmaceutical composition comprising a compound of claim 1 and a therapeutically inert carrier.

25. A method for the treatment or prophylaxis chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome, which method comprises administering an effective amount of a compound of claim 1 .