IP Library Granted Patent US 10,176,301
Granted Patent B2
US 10,176,301 · App. 14/851,695 · Granted Jan 8, 2019

Systems, methods, and software for providing a patient-reported outcome measure of dysphagia patients with eosinophilic esophagitis

Inventors: Malcolm Hill (Solana Beach, CA); Robert Farber (San Diego, CA); Bonnie Hepburn (Escondido, CA); Linda Gieschen (San Diego, CA)
Assignee: MERITAGE PHARMA, INC.
G06F19/345G16H10/20G16H10/60G16H50/20
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Quick Facts
Patent No.
US 10,176,301
App. No.
14/851,695
Granted
Jan 8, 2019
Kind
B2
Abstract

Provided herein are computer-based systems, software, and methods of using the same including a daily patient questionnaire, the questionnaire comprising: a question for determining whether the patient avoided solid food; a question for determining whether the patient had difficulty swallowing solid food; a question for determining what action the patient took to correct or relieve difficulty swallowing food; a question for determining the amount of pain the patient experienced while swallowing food; and a software module configured to apply an algorithm to answers to one or more of said questions to determine a score, wherein said score illustrates one or more selected from the group consisting of: (1) severity, intensity, or frequency of patient dysphagia; (2) suitability of a patient for a particular diagnostic tool, diagnostic method, or therapy for dysphagia; and (3) efficacy of a particular therapy for dysphagia.

Claims (18)

1. A method of treating dysphagia, the method comprising:

a. providing, via a digital processing device, a daily patient questionnaire to a patient as a diagnostic tool, said questionnaire comprising:

i. at least one of an avoidance question determining whether the patient avoided solid food;

ii. at least one of a frequency question determining frequency of the patient's symptom;

iii. at least one of a response question determining what action, if any, the patient took to correct or relieve the symptom;

iv. at least one of a pain question determining the amount of pain the patient experienced during the symptom;

wherein the questionnaire presents at least a three question combination of the avoidance question, the frequency question, the response question, and the pain question;

b. applying, via the digital processing device, an algorithm to answers to said combination of questions to determine a daily average score,

wherein the algorithm:

scores the at least one avoidance question from 0 to 1;

scores the at least one frequency question from 0 to 1;

scores the at least one response question from 0 to 5;

sums the scores of all the questions presented in the questionnaire; and

calculates the daily average score based on a plurality of scored questionnaires;

c. evaluating the daily average score against a threshold, and

d. administering a corticosteroid therapy to the patient when the daily average score exceeds the threshold.

2. The method of claim 1 , further comprising communicating patient answers to a centralized database via a software module.

3. The method of claim 1 , wherein the threshold is an average score per questionnaire between 1 and 2.

Assignments (4)
MERGER Recorded Jul 9, 2021
From: MERITAGE PHARMA, INC.
To: SHIRE VIROPHARMA LLC
Reel/Frame 056802/0233 →
MERGER Recorded Jul 9, 2021
From: SHIRE VIROPHARMA LLC
To: VIROPHARMA BIOLOGICS LLC
Reel/Frame 056802/0426 →
CHANGE OF ADDRESS Recorded Nov 28, 2018
From: MERITAGE PHARMA, INC.
To: MERITAGE PHARMA, INC.
Reel/Frame 048156/0853 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 29, 2018
From: HILL, MALCOLM; FARBER, ROBERT; HEPBURN, BONNIE; GIESCHEN, LINDA
To: MERITAGE PHARMA, INC.
Reel/Frame 047346/0956 →
Continuity (2)
Provisional Application 62049170 · Sep 11, 2014
Related Publication 20160078186A1 · Mar 17, 2016
Cited By (4)
US 12,290,598 US 12,310,976 US 12,447,157 US 12,691,128