Botulinum toxin and the treatment of primary disorders of mood and affect
A method of treating circadian rhythm disorders includes identifying a subject with a circadian rhythm disorder or at least one symptom of a circadian rhythm disorder and administering an effective amount of a composition comprising a botulinum toxin and a pharmaceutically acceptable carrier to said subject thereby reducing at least one symptom of a circadian rhythm disorder.
1. A method for simultaneously treating both sleep disorder and depression comprising:
(i) identifying a subject with both sleep disorder and depression; and
(ii) administering an effective amount of a composition comprising a botulinum toxin immunotype A and a pharmaceutically acceptable carrier to the subject, thereby reducing at least one symptom of both sleep disorder and depression;
wherein said sleep disorder is sleep onset insomnia or sleep maintenance insomnia.
2. The method of claim 1 , wherein the botulinum toxin is botulinum toxin type A from Hall strain Clostridium botulinum.
3. The method of claim 1 , wherein the composition is administered by an injection.
4. The method of claim 3 , wherein the step of administering the composition to the subject further comprises at least two injections sites, wherein the injections are multifocal.
5. The method of claim 3 , wherein the composition is administered to at least one of a forehead, scalp, neck, or periocular region of the subject.
6. The method of claim 3 , wherein the injection is transcutaneous, subcutaneous, transdermal, or intramuscular.
7. The method of claim 1 , wherein the effective amount of the composition is a dose between 5-3000 units.
8. The method of claim 1 , wherein the composition decreases choline acetyltransferase activity.
9. The method of claim 1 , wherein the composition decreases synthesis of acetylcholine.