Inhalable nicotine formulations and methods of making and using the same
The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components. The dry powder formulations may be manufactured by dry processes and wet processes.
1. A dry powder nicotine formulation comprising nicotine, lactose, and leucine, wherein the concentration of nicotine is between 0.5% and 10%, and wherein the formulation is suitable for inhalation.
2. The formulation of claim 1 , wherein the nicotine comprises at least one nicotine salt.
3. The formulation of claim 2 , wherein the at least one nicotine salt is nicotine tartrate.
4. The formulation of claim 1 , wherein the concentration of nicotine is about 0.5%.
5. The formulation of claim 1 , wherein the concentration of nicotine is about 1%.
6. The formulation of claim 1 , wherein the concentration of nicotine is about 1.5%.
7. The formulation of claim 1 , wherein the concentration of nicotine is about 2%.
8. The formulation of claim 1 , wherein the concentration of nicotine is about 2.5%.
9. The formulation of claim 1 , wherein the concentration of nicotine is about 3%.
10. The formulation of claim 1 , wherein the concentration of nicotine is about 3.5%.
11. The formulation of claim 1 , wherein the concentration of nicotine is about 4%.
12. The formulation of claim 1 , wherein the concentration of nicotine is about 4.5%.
13. The formulation of claim 1 , wherein the concentration of nicotine is about 5%.
14. The formulation of claim 1 , wherein the concentration of nicotine is about 10%.
15. The formulation of claim 1 , wherein the concentration of lactose is between 50% and 80%.
16. The formulation of claim 1 , wherein the concentration of lactose is between 50% and 99%.
17. The formulation of claim 1 , wherein the concentration of lactose is at least 50%.
18. The formulation of claim 1 , wherein the concentration of leucine is between 0.5% and 10%.
19. The formulation of claim 1 , further comprising at least one flavor component.
20. The formulation of claim 1 , further comprising at least one therapeutic agent.
21. The formulation of claim 20 , wherein the at least one therapeutic agent is a cough suppressant.
22. The formulation of claim 1 , further comprising menthol.
23. The formulation of claim 22 , wherein the concentration of menthol is between 0.5% and 20%.
24. The formulation of claim 1 , further comprising mint.
25. The formulation of claim 24 , wherein the concentration of mint is between 0.5% and 20%.
26. A kit for delivering a dry powder nicotine formulation of claim 1 , the kit comprising at least an amount of a nicotine formulation comprising nicotine particles, and an instruction material.