Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders
Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.
1. A nutrient formulation in an oral ingestion form for a daily dosage, comprising:
a. at least 3 milligrams of zeaxanthin that is present in 3R-3′R stereoisomer form and is substantially free of meso-zeaxanthin stereoisomers;
b. zinc at a dosage that does not exceed 40 milligrams of elemental zinc;
c. vitamin C that is presented in the form of ascorbic acid;
d. at least one tocopherol that provides anti-oxidant activity;
e. omega-3 fatty acids including docosa-hexaenoic acid (DHA) and eicosa-pentaenoic acid (EPA);
f. lipoic acid; and
wherein the nutrient formulation is provided in the form selected from the group consisting of capsules, tablets, liquids, and powders for oral ingestion.
2. The nutrient formulation of claim 1 , wherein the omega-3 fatty acids are derived from fish oil.
3. The nutrient formulation of claim 1 , wherein the nutrient formulation is present in a form that provides sustained release over a span of at least 3 hours following ingestion.
4. The nutrient formulation of claim 1 , wherein a plurality of capsules is required to achieve the at least 3 milligram daily dosage of zeaxanthin.
5. The nutrient formulation of claim 1 , wherein the daily dosage of zeaxanthin is at least 10 milligrams.
6. A nutrient formulation in an oral ingestion form for a daily dosage, comprising:
a. at least 3 milligrams of zeaxanthin that is present in 3R-3′R stereoisomer form and is substantially free of meso-zeaxanthin stereoisomers;
b. zinc at a dosage that does not exceed 40 milligrams of elemental zinc;
c. vitamin C that is presented in the form of ascorbic acid;
d. at least one tocopherol that provides anti-oxidant activity, the at least one tocopheral including vitamin E; and
wherein the nutrient formulation is presented in the form of pills or capsules that contain oily carrier materials to increase the uptake of the nutrient formulation.
7. The nutrient formulation of claim 6 , further comprising omega-3 fatty acids.
8. The nutrient formulation of claim 7 , wherein the omega-3 fatty acids are derived from fish oil.
9. The nutrient formulation of claim 6 , wherein said nutrient formulation is present in a form that provides sustained release over a span of at least 3 hours following ingestion.
10. The nutrient formulation of claim 6 , wherein the daily dosage of zeaxanthin is at least 10 milligrams.
11. The nutrient formulation of claim 6 , wherein the formulation further includes lipoic acid.
12. The nutrient formulation of claim 6 , wherein the formulation is in the form of capsules containing oily carrier materials.
13. The nutrient formulation of claim 1 , wherein the formulation is in the form of capsules containing oily carrier materials.
14. The nutrient formulation of claim 1 , wherein the at least one tocopherol includes vitamin E.