Energy delivery systems and uses thereof
The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.
1. A method of treating a peripheral lung tissue region in a subject, comprising
steering a microwave energy delivery device through the subject's lung and positioning the microwave energy delivery device at a target peripheral lung tissue region, and ablating the target peripheral lung tissue region with energy from the microwave energy delivery device,
wherein the steering is through the subject's mouth, through the subject's trachea, and through the subject's lung,
wherein the microwave energy delivery device is of sufficient length to extend from the mouth of a human subject, through the trachea of the human subject, into the lung of the human subject and to the peripheral lung of the human subject;
wherein the diameter of the microwave energy delivery device is approximately 2 mm or less;
wherein the microwave energy delivery device is flexible;
wherein the microwave energy delivery device comprises an inner conductor, an outer conductor, and a stylet tip,
the inner conductor is a conductor of microwave energy,
the outer conductor is a conductor of microwave energy,
the inner conductor having a proximal end and a distal end,
the outer conductor having a proximal end and a distal end,
the stylet tip having a proximal end and a distal end,
the stylet tip attached at the distal end of the microwave energy delivery device;
wherein the microwave energy delivery device has therein one or more coolant channels for circulating and recirculating coolant, wherein the one or more coolant channels does not extend to the distal end of the stylet tip;
wherein the microwave energy delivery device has thereon a temperature sensor.
2. The method of claim 1 , wherein the steering comprises
advancing a hollow primary catheter having a hollow channel catheter therein through the subject's mouth, through the subject's trachea, and through the subject's lung until further advance is constrained by the diameter of the hollow primary catheter, wherein the hollow channel catheter has therein a steerable navigation catheter,
advancing the hollow channel catheter having the steerable navigation catheter therein beyond the distal end of the hollow primary catheter and extending the hollow channel catheter having the steerable navigation catheter therein through the subject's lung and to the target peripheral lung tissue region,
withdrawing the steerable navigation catheter from the hollow channel catheter,
inserting the microwave energy delivery device through the hollow channel catheter such that it is positioned at the target peripheral lung tissue region.
3. The method of claim 2 ,
wherein advancing the hollow channel catheter having the steerable navigation catheter therein beyond the distal end of the hollow primary catheter and extending the hollow channel catheter having the steerable navigation catheter therein through the subject's lung comprises extending the hollow channel catheter having the steerable navigation catheter therein through one or more of primary bronchial tissue, secondary bronchial tissue, tertiary bronchial tissue, and bronchiole tissue.
4. The method of claim 2 , wherein the steerable navigation catheter controls the advancing.
5. The method of claim 1 , wherein the microwave energy delivery device comprises a braided material.
6. The method of claim 1 , wherein ablating the target peripheral lung tissue region with energy from the microwave energy delivery device is controlled with a processor.
7. The method of claim 1 , wherein the microwave energy delivery device is in electrical communication with an energy power supply.
8. The method of claim 1 , wherein the inner conductor is hollow.
9. The method of claim 1 , wherein a dielectric material is positioned between the inner conductor and the outer conductor.
10. The method of claim 1 , wherein the inner conductor and the outer conductor comprise air channels.
11. The method of claim 1 , wherein the target peripheral lung tissue region comprises lung nodule tissue.
12. The method of claim 1 , wherein the target peripheral lung tissue region comprises lung tumor tissue.
13. The method of claim 1 , wherein the target peripheral lung tissue region comprises lung lesion tissue.
14. The method of claim 1 , wherein the target peripheral lung tissue region comprises cancerous tissue.
15. The method of claim 1 , wherein one or more stabilization and/or anchoring mechanisms are used to secure one or more of the hollow primary catheter, the hollow channel catheter, the steerable navigation catheter, and the microwave energy delivery device at a desired tissue region.
16. The method of claim 15 , where the desired tissue region is the target peripheral lung tissue region.
17. The method of claim 1 , wherein the microwave energy delivery device is configured to detect an undesired rise in temperature within the microwave energy delivery device and automatically or manually reduce such an undesired temperature rise through flowing of coolant through the one or more coolant channels.
18. The method of claim 1 , wherein the microwave energy delivery device is a triaxial microwave probe.
19. The method of claim 18 , wherein the triaxial microwave probe comprises optimized tuning capabilities to reduce reflective heat loss.
20. The method of claim 18 , wherein the triaxial antenna comprises an inner conductor, a dielectric material, and an outer conductor, wherein the dielectric material is between the inner conductor and the outer conductor.