IP Library › Granted Patent US 9,629,862
Granted Patent B2
US 9,629,862 · App. 14/871,450 · Granted Apr 25, 2017

Pantothenate derivatives for the treatment of neurologic disorders

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Quick Facts
Patent No.
US 9,629,862
App. No.
14/871,450
Granted
Apr 25, 2017
Kind
B2
Abstract

The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

Claims (18)

1. A pharmaceutical composition comprising (a) a compound of formula:

or a pharmaceutically acceptable salt thereof, wherein R, R′, and R″ are methyl; and (b) a pharmaceutically acceptable excipient.

2. A pharmaceutical composition comprising (a) a compound of formula:

or a pharmaceutically acceptable salt thereof, wherein R is methyl, R′ is methyl, ethyl, methylcyclopropyl, or benzyl, and R″ is methyl, ethyl, methylcyclopropyl, or benzyl; and (b) a pharmaceutically acceptable excipient.

3. The pharmaceutical composition of claim 2 , wherein R′ is methyl.

4. The pharmaceutical composition of claim 2 , wherein R′ is ethyl.

5. The pharmaceutical composition of claim 2 , wherein R′ is methylcyclopropyl.

6. The pharmaceutical composition of claim 2 , wherein R′ is benzyl.

7. The pharmaceutical composition of claim 2 , wherein R″ is methyl.

8. The pharmaceutical composition of claim 2 , wherein R″ is ethyl.

9. The pharmaceutical composition of claim 2 , wherein R″ is methylcyclopropyl.

10. The pharmaceutical composition of claim 2 , wherein R″ is benzyl.

11. The pharmaceutical composition of claim 3 , wherein R″ is ethyl.

12. The pharmaceutical composition of claim 3 , wherein R″ is methylcyclopropyl.

13. The pharmaceutical composition of claim 3 , wherein R″ is benzyl.

14. The pharmaceutical composition of claim 7 , wherein R′ is ethyl.

15. The pharmaceutical composition of claim 7 , wherein R′ is methylcyclopropyl.

16. The pharmaceutical composition of claim 7 , wherein R′ is benzyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2016
From: VAINO, ANDREW; BIESTEK, MAREK; SHKRELI, MARTIN
To: RETROPHIN, INC.
Reel/Frame 039112/0037 →