IP Library Granted Patent US 10,274,433
Granted Patent B1
US 10,274,433 · App. 14/872,060 · Granted Apr 30, 2019

Device and method of measuring animal health

Inventors: Jonathan Betts-Lacroix (Belmont, CA); Laura R. Schaevitz (Los Gatos, CA); Kyle Howard Heath (Menlo Park, CA)
Assignee: Vium, Inc.
G01N21/78G01N2021/752G01N2021/7759G01N2021/7793
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Quick Facts
Patent No.
US 10,274,433
App. No.
14/872,060
Granted
Apr 30, 2019
Kind
B1
Abstract

A test pad comprising multiple test patches and urine detection patches in an array is described. The test pad is suitable for automated urine analysis of multiple animals in a cage. Urine detection patches may be arranged in a BAYER pattern or as rings. Multiple layers, including a substrate, a wicking layer, a test patch layer, and optional protection layer serve to manage puddles of urine. Various isolation elements are described that keep urine puddles from spreading. Color reference spots on the pad are used for dynamic color determination of test patches. Urine detection patches start a read clock and identify which test patches are valid. Elements to hold and align the test pad are described. Methods of detection and reading are described.

Claims (32)

1. A device for measuring attributes of urine comprising:

a pad comprising a test patch layer comprising:

a plurality of different urine test patches, each different urine test patch comprising one or more respective urine test chemicals that change color responsive to a respective urine attribute;

a plurality of urine detection patches, wherein the urine detection patches are different from any urine test patch, and wherein each urine detection patch comprises one or more chemicals that change color responsive to presence of urine;

wherein each different urine test patch is at least partially surrounded by one or more of the urine detection patches;

the urine detection patches and urine test patches are arranged in a BAYER pattern, wherein the urine detection patches are arranged in a checkerboard pattern within the BAYER pattern and the urine test patches are distributed among the remaining location in the BAYER pattern;

a wicking layer above the test patch layer;

a transparent protection layer with holes, above the wicking layer;

a non-porous substrate below the test patch layer;

wherein the urine detection patches and the urine test patches are on the test patch layer.

2. A device for measuring attributes of urine comprising:

a pad comprising a test patch layer comprising:

a plurality of different urine test patches, each different urine test patch comprising one or more respective urine test chemicals that change color responsive to a respective urine attribute;

a plurality of urine detection patches, wherein the urine detection patches are different from any urine test patch, and wherein each urine detection patch comprises one or more chemicals that change color responsive to presence of urine;

wherein each different urine test patch is at least partially surrounded by one or more of the urine detection patches;

the urine detection patches and urine test patches are arranged in a BAYER pattern, wherein the urine detection patches are arranged in a checkerboard pattern within the BAYER pattern and the urine test patches are distributed among the remaining location in the BAYER pattern;

a protection layer above the test patch layer, transparent or translucent;

comprising holes adapted to pass urine from above the top layer into the test patch layer;

a urine impenetrable substrate layer below the test patch layer.

3. The device of claim 1 wherein:

a color of each detection patch and a color of each test patch layer are viewable through the wicking layer.

4. The device of claim 1 further comprising:

at least one scent region comprising a chemical scent attractive to a single sex of a rodent.

5. The device of claim 1 further comprising:

at least one scent region comprising a chemical scent attractive to a single sex of a rodent.

6. The device of claim 1 further comprising:

well boundaries in the substrate layer comprising previously melted portions of the substrate layer;

wherein wells are defined by the well boundaries;

and wherein the wells are fluidly isolated from each other;

and wherein each well comprises at least one urine detection patch and at least one urine test patch.

7. The device of claim 1 wherein:

portions of the wicking layer protrude into the holes in the transparent protection layer.

Assignments (12)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2024
From: VIUM (ABC), LLC
To: RECURSION PHARMACEUTICALS, INC.
Reel/Frame 068799/0961 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2024
From: BETTS-LACROIX, JONATHAN
To: MOUSERA, INC.
Reel/Frame 068665/0160 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2024
From: HEATH, KYLE HOWARD
To: MOUSERA, INC.
Reel/Frame 068667/0713 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2024
From: SCHAEVITZ, LAURA R
To: MOUSERA, INC.
Reel/Frame 068667/0922 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTIES NAME FROM RECURSION PHARMACEUTICALS, INC. TO VIUM (ABC) LLC AND PROPERTY NUMBERS FROM 34 TO 42 TOTAL ATTACHMENTS FROM 19 PAGES TO 9 PAGES PREVIOUSLY RECORDED ON REEL 54439 FRAME 362. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT . Recorded Mar 25, 2024
From: VIUM, INC.
To: VIUM (ABC) LLC
Reel/Frame 066893/0379 →
CORRECTIVE ASSIGNMENT TO CORRECT THE D877354 PREVIOUSLY RECORDED AT REEL: 055620 FRAME: 0040. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SERCURITY INTEREST. Recorded Aug 4, 2021
From: SILICON VALLEY BANK
To: RECURSION PHARMACEUTICALS, INC.
Reel/Frame 057086/0684 →
CORRECTIVE ASSIGNMENT TO CORRECT THE THE APPLICATION NUMBER PREVIOUSLY RECORDED AT REEL: 053047 FRAME: 0191. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 4, 2021
From: VIUM, INC.
To: SILICON VALLEY BANK
Reel/Frame 057085/0787 →
RELEASE OF SECURITY INTEREST Recorded Mar 16, 2021
From: SILICON VALLEY BANK
To: RECURSION PHARMACEUTICALS, INC.
Reel/Frame 055620/0040 →
NUNC PRO TUNC ASSIGNMENT Recorded Nov 22, 2020
From: VIUM, INC.
To: RECURSION PHARMACEUTICALS, INC.
Reel/Frame 054439/0362 →
NUNC PRO TUNC ASSIGNMENT Recorded Nov 22, 2020
From: VIUM, INC.
To: RECURSION PHARMACEUTICALS, INC.
Reel/Frame 054439/0387 →
SECURITY INTEREST Recorded Jun 25, 2020
From: VIUM, INC.
To: SILICON VALLEY BANK
Reel/Frame 053047/0192 →
NUNC PRO TUNC ASSIGNMENT Recorded May 3, 2017
From: MOUSERA, INC.
To: VIUM, INC
Reel/Frame 042226/0673 →