IP Library Granted Patent US 10,272,607
Granted Patent B2
US 10,272,607 · App. 14/872,672 · Granted Apr 30, 2019

Manufacturing of small film strips

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Quick Facts
Patent No.
US 10,272,607
App. No.
14/872,672
Granted
Apr 30, 2019
Kind
B2
Abstract

The present invention relates to methods and apparatuses for forming films. In particular, the present invention relates to the formation of films on a substrate via the use of individual pumps to deposit individual wet film products onto a substrate. A method of forming film products includes: providing a reservoir housing a film forming matrix, pumps in association with the reservoir, and orifices; feeding the wet film forming matrix from the reservoir to the pumps; dispensing the film forming matrix from each of the pumps through an orifice; and depositing wet film products onto a substrate. An apparatus for forming film strips includes: (a) a reservoir for housing a film forming matrix; (b) pumps associated with the reservoir; (c) a plurality of orifices, with each orifice being associated with a pump; (d) a substrate; and (e) a means for moving the substrate through the apparatus.

Claims (50)

1. A method of forming a plurality of individual film products, comprising the steps of:

(a) providing a reservoir housing a film forming matrix;

(b) providing a plurality of individual volumetric pumps in association with said reservoir;

(c) providing a feed line which connects said reservoir to each of said individual volumetric pumps; wherein said feed line feeds the film forming matrix to each of said individual volumetric pumps in a parallel fashion so that each individual volumetric pump is fed with film forming matrix on a substantially equal basis;

(d) providing a substrate that moves under said plurality of individual volumetric pumps; and

(e) dispensing substantially the same amount of film forming matrix from each of said individual volumetric pumps to form lanes of sequential individual wet film products on said substrate as said substrate moves under said plurality of individual volumetric pumps, wherein each of said individual volumetric pumps forms its own lane of sequential individual wet film products.

2. The method of claim 1 , wherein said substrate is a backing film.

3. The method of claim 1 , wherein said substrate moves to a drying oven.

4. The method of claim 1 , wherein each of said individual volumetric pumps dispenses about 3 microliters to about 250 microliters per stroke.

5. The method of claim 4 , wherein each of said individual volumetric pumps dispenses about 4 microliters to about 250 microliters per stroke.

6. The method of claim 1 , wherein said film forming matrix is at least 25% solids.

7. The method of claim 1 , further comprising the step:

(f) drying said sequential individual wet film products to form dried individual film products.

8. The method of claim 7 , wherein said dried individual film products are die cut.

9. The method of claim 7 , wherein each of said dried individual film products is for the delivery of a desired amount of active.

10. The method of claim 9 , wherein each of said dried individual film products comprises active in an amount which varies by no more than about 10% from said desired amount of active.

11. The method of claim 1 , wherein said individual volumetric pumps are piston pumps.

12. The method of claim 1 , wherein each of said individual wet film products has substantially uniform content with respect to each individual wet film product.

13. The method of claim 1 , wherein each of said individual volumetric pumps dispenses about 250 microliters or less per pumping cycle.

14. The method of claim 1 , wherein each of said individual volumetric pumps dispenses from about 30 microliters to about 10 milliliters per pumping cycle.

15. The method of claim 1 , wherein each of said lanes comprises a plurality of sequential individual wet film products.

16. The method of claim 1 , wherein the film forming matrix comprises an active.

17. An apparatus for forming a plurality of individual film products, comprising:

(a) a reservoir housing a film forming matrix;

(b) a plurality of individual volumetric pumps associated with said reservoir;

(c) a feed line which connects said reservoir to each of said individual volumetric pumps; wherein said feed line feeds the film forming matrix to each of said individual volumetric pumps in a parallel fashion so that each individual volumetric pump is fed with film forming matrix on a substantially equal basis; and

(d) a substrate which moves under said plurality of individual volumetric pumps;

wherein each of said individual volumetric pumps dispenses substantially the same amount of film forming matrix to form lanes of individual wet film products on said substrate when said substrate moves under said plurality of individual volumetric pumps through said apparatus, wherein each of said individual volumetric pumps forms its own lane of sequential individual wet film products, and wherein said substrate comprises lanes of sequential individual wet film products.

18. The apparatus of claim 17 , wherein said reservoir is pressurized.

19. The apparatus of claim 17 , wherein said individual volumetric pumps are rotating piston pumps.

20. The apparatus of claim 17 , wherein each of said individual volumetric pumps dispenses about 3 microliters to about 250 microliters per stroke.

21. The apparatus of claim 20 , wherein each of said individual volumetric pumps dispenses about 4 microliters to about 250 microliters per stroke.

22. The apparatus of claim 17 , wherein the individual wet film products are small film products.

23. The apparatus of claim 17 , further comprising a drying oven.

24. The apparatus of claim 17 , wherein each of said individual volumetric pumps dispenses about 250 microliters or less per pumping cycle.

25. The apparatus of claim 17 , wherein each of said individual volumetric pumps dispenses from about 30 microliters to about 10 milliliters per pumping cycle.

26. The apparatus of claim 17 , wherein each of said lanes comprises a plurality of sequential individual wet film products.

27. The apparatus of claim 17 , wherein the film forming matrix comprises an active.

28. A method of forming a plurality of individual film patches, comprising the steps of:

(a) providing a substrate comprising a sheet of dissolvable polymeric material, said sheet having a top surface;

(b) providing a reservoir housing a wet film forming matrix, said wet film forming matrix comprising a second polymeric material and an active;

(c) providing a plurality of individual volumetric pumps in association with said reservoir; wherein said substrate moves under said plurality of individual volumetric pumps;

(d) providing a feed line which connects said reservoir to each of said individual volumetric pumps; wherein said feed line feeds the film forming matrix to each of said individual volumetric pumps in a parallel fashion so that each individual volumetric pump is fed with film forming matrix on a substantially equal basis;

(e) dispensing substantially the same amount of said film forming matrix from each of said individual volumetric pumps to form lanes of sequential individual wet film products on said top surface of said sheet as said substrate moves under said plurality of individual volumetric pumps, wherein each of said individual volumetric pumps forms its own lane of sequential individual wet film products; and

(f) drying said sequential individual wet film products to form a plurality of multi-layer film patches comprising a first layer comprising said sheet and a second layer comprising a dried film product.

29. The method of claim 28 , wherein each of said individual volumetric pumps dispenses about 3 microliters to about 250 microliters per stroke.

30. The method of claim 28 , wherein each of said individual volumetric pumps dispenses about 250 microliters or less per pumping cycle.

31. The method of claim 28 , wherein each of said individual volumetric pumps dispenses from about 30 microliters to about 10 milliliters per pumping cycle.

32. The method of claim 28 , wherein each of said lanes comprises a plurality of sequential individual wet film products.

33. The method of claim 28 , wherein said substrate continuously moves in a first direction under said plurality of individual volumetric pumps.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded May 13, 2026
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION
To: AQUESTIVE THERAPEUTICS, INC.
Reel/Frame 075646/0258 →
SECURITY INTEREST Recorded May 12, 2026
From: AQUESTIVE THERAPEUTICS, INC.
To: OAKTREE FUND ADMINISTRATION, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 075561/0782 →
SECURITY INTEREST Recorded Nov 2, 2023
From: AQUESTIVE THERAPEUTICS, INC.
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION
Reel/Frame 065446/0494 →
RELEASE OF SECURITY INTEREST Recorded Nov 1, 2023
From: U.S. BANK TRUST COMPANY NATIONAL ASSOCIATION (AS SUCCESSOR IN INTEREST TO U.S BANK NATIONAL ASSOCIATION)
To: AQUESTIVE THERAPEUTICS, INC.
Reel/Frame 065426/0642 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2019
From: BOGUE, BEUFORD A.
To: MONOSOL RX, LLC
Reel/Frame 050276/0875 →
RELEASE OF SECURITY INTEREST Recorded Jul 15, 2019
From: PERCEPTIVE CREDIT HOLDINGS, LP
To: AQUESTIVE THERAPEUTICS, INC.; MONOSOL RX, INC.; MSRX US, LLC
Reel/Frame 049757/0733 →
SECURITY INTEREST Recorded Jul 15, 2019
From: AQUESTIVE THERAPEUTICS, INC.
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 049758/0082 →
AMENDMENT TO PATENT SECURITY AGREEMENT RECORDED AT REEL/FRAME 039707/0194 Recorded Jan 30, 2018
From: AQUESTIVE THERAPEUTICS, INC.
To: PERCEPTIVE CREDIT HOLDINGS, LP
Reel/Frame 045279/0802 →
CHANGE OF NAME Recorded Jan 29, 2018
From: MONOSOL RX, LLC
To: AQUESTIVE THERAPEUTICS, INC.
Reel/Frame 045196/0389 →
SECURITY INTEREST Recorded Aug 16, 2016
From: MONOSOL RX, LLC; MONOSOL RX, INC.; MSRX US, LLC
To: PERCEPTIVE CREDIT HOLDINGS, LP
Reel/Frame 039707/0194 →