Systems and methods for multi-analysis
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
1. A cartridge for use with a sample processing device, said cartridge comprising:
at least one sample collection unit;
at least one tip;
at least one reagent unit;
at least one assay unit;
at least one thermal device; and
a cartridge frame for supporting all of the foregoing and configured to be at least partially inserted into the sample processing device, wherein the at least one thermal device is mounted to the frame to position the at least one thermal device to thermally condition the at least one reagent unit.
2. The cartridge of claim 1 , wherein the at least one reagent unit and the at least one assay unit are fluidically isolated and movable.
3. The cartridge of claim 1 , wherein the at least one thermal device is capable of heating the cartridge.
4. The cartridge of claim 1 , wherein the at least one thermal device is capable of cooling the cartridge.
5. The cartridge of claim 1 , wherein the at least one thermal device thermally controls the temperature of a part of the cartridge without thermally affecting other parts of the cartridge.
6. The cartridge of claim 1 , wherein the at least one thermal device comprises a chemical reaction pack.
7. The cartridge of claim 6 , wherein the chemical reaction pack comprises at least one chemical selected from sodium acetate, calcium chloride, magnesium, iron, and sodium chloride.
8. The cartridge of claim 1 , wherein the cartridge comprises at least two thermal devices, wherein the at least two thermal devices comprises a first thermal device and a second thermal device.
9. The cartridge of claim 8 , wherein the first thermal device and the second thermal device are placed at different locations of the cartridge.
10. The cartridge of claim 8 , wherein the first thermal device and the second thermal device are different sizes.
11. The cartridge of claim 1 , further comprising at least one thermally conductive material coupled to predetermined portions of the frame.
12. The cartridge of claim 11 , wherein the at least one thermally conductive material comprises at least one metal selected from aluminum, copper, silver, gold, steel, brass, iron, titanium, nickel, or any combination thereof.
13. The cartridge of claim 11 , wherein the at least one thermally conductive material and the cartridge are made of different material.
14. The cartridge of claim 11 , wherein the at least one thermally conductive material is integrated into a material used to form the cartridge.
15. The cartridge of claim 11 , wherein the at least one thermally conductive material is located over the at least one thermal device.
16. The cartridge of claim 11 , wherein the at least one thermally conductive material is spaced apart from the at least one thermal device.
17. The cartridge of claim 11 , wherein the thermally conductive material is in contact with the at least one sample collection unit, the at least one tip, the at least one reagent unit, and/or the at least one assay unit.
18. The cartridge of claim 11 , wherein the cartridge comprises at least two thermally conductive materials.
19. A cartridge for use with a sample processing device, said cartridge comprising:
at least one sample collection unit;
at least one tip;
at least one reagent unit;
at least one assay unit;
at least one thermal device; and
a cartridge frame for supporting all of the foregoing and configured to be at least partially inserted into the sample processing device, wherein the at least one thermal device is mounted to the frame to position the at least one thermal device to thermally condition the at least one reagent unit;
wherein the cartridge comprises all reagents for performing one or more assays on a biological sample obtained from a subject.
20. A cartridge for use with a sample processing device, said cartridge comprising:
at least one sample collection unit;
at least one tip;
at least one reagent unit;
at least one assay unit;
at least one thermal device; and
a cartridge frame for supporting all of the foregoing and configured to be at least partially inserted into the sample processing device, wherein the at least one thermal device is mounted to the frame to position the at least one thermal device to thermally condition the at least one reagent unit;
wherein the at least one sample collection unit is configured to receive a blood sample of no more than about 500 μl.