Solution for drug discovery
A drug discovery system may include a data platform and a drug discovery module. The data platform may be scalable to include a plurality of data sources. The data sources may include at least a clinical research database providing results of clinical trials. The drug discovery module may include a pharmaco-genomic mapper configured to provide a mapping of drugs to biomarkers based on extraction of information from the data sources, and a genome connect module configured to provide a mapping of biomarkers to diseases based on extraction of information from the data sources. The drug discovery module may include processing circuitry configured to provide a potential drug to disease link based on the mapping of drugs to biomarkers and the mapping of biomarkers to diseases using the biomarkers as a bridge.
1. A drug discovery system, the system comprising:
a data platform scalable to include a plurality of data sources, the data sources including at least a clinical research database providing matched data and not matched data from results of clinical trials;
a drug discovery module comprising a pharmaco-genomic mapper configured to analyze terabytes of data from the data sources to:
evaluate the matched data to define a mapping of drugs to biomarkers determined based on a first qualitative and quantitative assessment to have a first mapping score above a first threshold, and
evaluate the not matched data to include at least some of the not matched data within the mapping of drugs to biomarkers determined based on the first qualitative and quantitative assessment to have the first mapping score above the first threshold; and
a genome connect module configured to:
evaluate the matched data to define a mapping of biomarkers to diseases determined based on a second qualitative and quantitative assessment to have a second mapping score above a second threshold, and
evaluate the not matched data to include at least some of the not matched data within the mapping of biomarkers to diseases determined based on the second qualitative and quantitative assessment to have the second mapping score above the second threshold,
the drug discovery module comprising processing circuitry configured to provide a potential drug to disease link based on the mapping of drugs to biomarkers and the mapping of biomarkers to diseases using the biomarkers as a bridge between respective mappings,
wherein the first and second mapping scores indicate a level of validation for each respective mapping.
2. The system of claim 1 , further comprising a user interface component configured to enable a user to provide a query, and to generate a response to the query, the response providing the potential drug to disease link.
3. The system of claim 2 , wherein the query defines a drug, a disease or a biomarker, and wherein the response defines a list of potential drug to disease links including the drug, the disease or the biomarker.
4. The system of claim 3 , wherein the list is defined based on the potential drug to disease links that have a composite mapping score greater than a predefined threshold.
5. The system of claim 4 , wherein the composite mapping score comprises the first mapping score for the mapping of drugs to biomarkers and the second mapping score for the mapping of biomarkers to diseases.
6. The system of claim 5 , wherein at least one of the first mapping score or the second mapping score includes an indicator of data quantity.
7. The system of claim 5 , wherein at least one of the first mapping score or the second mapping score includes an indicator of data quality.
8. The system of claim 7 , wherein the indicator of data quality is defined based on an assessment of a number of biomarkers associated with the disease for which a biomarker to disease mapping is indicated in the data sources.
9. The system of claim 7 , wherein the indicator of data quality is defined based on an assessment of an identity of biomarkers associated with the disease for which a biomarker to disease mapping is indicated in the data sources.
10. The system of claim 3 , wherein the list is provided in rank order or alphabetical order.
11. The system of claim 2 , wherein the system further comprises an analytics platform configured to interface with the data sources to selectively identify correlations based on analysis of contents of the data sources responsive to the query and a modeling component configured to apply a selected model, based on the query, to at least in part define the response.
12. A method of drug discovery, the method comprising:
accessing information associated with genetic markers from a data platform scalable to include a plurality of data sources, the data sources including at least a clinical research database providing matched data and not matched data from results of clinical trials;
employing a drug discovery module to analyze terabytes of data from the data sources to:
evaluate the matched data to define a mapping of drugs to biomarkers determined based on a first qualitative and quantitative assessment to have a first mapping score above a first threshold, and
evaluate the not matched data to include at least some of the not matched data within the mapping of drugs to biomarkers determined based on the first qualitative and quantitative assessment to have the first mapping score above the first threshold; and
employing the drug discovery module to:
evaluate the matched data to define a mapping of biomarkers to diseases determined based on a second qualitative and quantitative assessment to have second mapping score above a second threshold, and
evaluate the not matched data to include at least some of the not matched data within the mapping of biomarkers to diseases determined based on the second qualitative and quantitative assessment to have the second mapping score above the second threshold,
the drug discovery module comprising processing circuitry configured to provide a potential drug to disease link based on the mapping of drugs to biomarkers and the mapping of biomarkers to diseases using the biomarkers as a bridge between respective mappings,
wherein the first and second mapping scores indicate a level of validation for each respective mapping.
13. The method of claim 12 , further comprising receiving a query from a user, and generating a response to the query, the response providing the potential drug to disease link.
14. The method of claim 13 , wherein the query defines a drug, a disease or a biomarker, and wherein the response defines a list of potential drug to disease links including the drug, the disease or the biomarker.
15. The method of claim 14 , wherein the list is defined based on the potential drug to disease links that have a composite mapping score greater than a predefined threshold.
16. The method of claim 15 , wherein the composite mapping score comprises the first mapping score for the mapping of drugs to biomarkers and the second mapping score for the mapping of biomarkers to diseases.
17. The method of claim 16 , wherein at least one of the first mapping score or the second mapping score includes an indicator of data quantity.
18. The method of claim 16 , wherein at least one of the first mapping score or the second mapping score includes an indicator of data quality.
19. The method of claim 18 , wherein the indicator of data quality is defined based on an assessment of a number of biomarkers associated with the disease for which a biomarker to disease mapping is indicated in the data sources.
20. The method of claim 18 , wherein the indicator of data quality is defined based on an assessment of an identity of biomarkers associated with the disease for which a biomarker to disease mapping is indicated in the data sources.