Compositions and methods of using (R)-pramipexole
Pharmaceutical compositions of (R)-pramipexole and one or more secondary therapeutic agents such as, for example, dopamine agonists, dopaminergic agonists, COMT inhibitors, MOA inhibitors, excitatory amino acid antagonists, growth factors, neurotrophic factors, antioxidants, anti-inflammatory agents, immunomodulators, anti-glutamatergics, ion channel blockers, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, heat shock protein inducers/protein disaggregators and downregulators, monoamine oxidase type B (MOAB) inhibitors, multi-target agents, kinase inhibitors, Bcl inducers, histone deacetylase (HDAC) mediators, glial modulators, mitochondrial energy promoting agents, myostatin inhibitors, caspase inhibitors and combinations thereof or those related to mitochondrial dysfunction or increased oxidative stress are disclosed.
1. A method of treating amyotrophic lateral sclerosis (ALS) in a patient comprising:
administering to the patient a single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof; and
administering adjunctively to the patient a therapeutically effective amount of creatine.
2. The method of claim 1 , further comprising administering a mitochondrial energy promoting agent selected from the group consisting of resveratrol; erythropoietin; cholest-4-en-3-One, oxime (TRO-19622); and any combination thereof.
3. The method of claim 1 , wherein the steps of administering the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof and administering the therapeutically effective amount of creatine occurs concurrently.
4. The method of claim 1 , wherein the steps of administering the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof and administering the therapeutically effective amount of creatine occurs separately.
5. The method of claim 1 , wherein the steps of administering the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof and administering the therapeutically effective amount of creatine each individually occur one or more times in a 24-hour period.
6. The method of claim 1 , wherein the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine, or pharmaceutically acceptable salt thereof, has a 99.90% or greater chiral purity.
7. The method of claim 1 , wherein the single unit dose comprises at least about 200 mgs of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof.
8. The method of claim 1 , wherein the single unit dose comprises at least about 300 mgs of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof.
9. The method of claim 1 , wherein the single unit dose further comprises less than about 1.0 mg of (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof.
10. The method of claim 1 , comprising a course of treatment wherein the steps of administering the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof and administering the therapeutically effective amount of creatine is repeated one or more times in a 24-hour period for 5 days to one or more years.
11. The method of claim 1 , wherein the single unit dose of at least 150 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof is a pharmaceutically acceptable salt of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine.
12. The method of claim 1 , wherein the pharmaceutically acceptable salt is (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine dihydrochloride monohydrate.
13. A method of treating amyotrophic lateral sclerosis (ALS) in a patient comprising:
administering to the patient a single unit dose of about 150 milligrams to about 5,000 milligrams of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine or a pharmaceutically acceptable salt thereof in a pharmaceutical composition; and
administering adjunctively to the patient a therapeutically effective amount of creatine.
14. The method of claim 13 , further comprising administering a mitochondrial energy promoting agent selected from the group consisting of resveratrol; erythropoietin; cholest-4-en-3-One, oxime (TRO-19622); and any combination thereof.