IP Library › Granted Patent US 9,796,718
Granted Patent B2
US 9,796,718 · App. 14/882,278 · Granted Oct 24, 2017

6-(benzo[d]thiazol-5-yl)-n-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine

Inventors: Scott A. Mitchell (East Haven, CT); Kevin S. Currie (North Branford, CT); Peter A. Blomgren (North Branford, CT); Jeffrey E. Kropf (Branford, CT); Seung H. Lee (Branford, CT); Jianjun Xu (Madison, CT); Douglas G. Stafford (Niskayuna, NY); James P. Harding (East Greenbush, NY); Antonio J. M. Barbosa, Jr. (Bonita Springs, FL); Zhongdong Zhao (Guilford, CT); David M. Armistead (Sudbury, MA); Soumya Mitra (Liverpool, NY)
Assignee: Gilead Connecticut, Inc.
C07D487/04A61K31/495C07D471/04C07D491/107C07D498/04C07D519/00C12Q1/485G01N33/573G01N2333/91205
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Quick Facts
Patent No.
US 9,796,718
App. No.
14/882,278
Granted
Oct 24, 2017
Kind
B2
Abstract

Provided are imidazopyrazine compounds, particularly including 6-(benzo[d]thiazol-5-yl)-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine, structure below, and methods and formulations for their use in inhibiting Spleen Tyrosine Kinase in treating conditions including B-cell lymphomas or leukemias and inflammatory conditions:

Claims (3)

1. A compound having the structure:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2020
From: GILEAD CONNECTICUT, INC.
To: KRONOS BIO, INC.
Reel/Frame 053927/0969 →
MERGER AND CHANGE OF NAME Recorded Sep 17, 2020
From: COUGAR MERGER SUB, INC.; CGI PHARMACEUTICALS, INC.; CGI PHARMACEUTICALS, INC.
To: GILEAD CONNECTICUT, INC.
Reel/Frame 053799/0190 →
CORRECTIVE ASSIGNMENT TO CORRECT THE TENTH INVENTOR NAME PREVIOUSLY RECORDED AT REEL: 043548 FRAME: 0294. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 6, 2017
From: MITCHELL, SCOTT A.; CURRIE, KEVIN S.; BLOMGREN, PETER A.; KROPF, JEFFREY E.; LEE, SEUNG H.; XU, JIANJUN; STAFFORD, DOUGLAS G.; HARDING, JAMES P.; BARBOSA, ANTONIO J., JR.; ZHAO, ZHONGDONG
To: CGI PHARMACEUTICALS, INC.
Reel/Frame 044144/0226 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2017
From: MITCHELL, SCOTT A.; CURRIE, KEVIN S.; BLOMGREN, PETER A.; KROPF, JEFFREY E.; LEE, SEUNG H.; XU, JIANJUN; STAFFORD, DOUGLAS G.; HARDING, JAMES P.; BARBOSA, ANTONIO J., JR.; ZHAO, ZHONDONG
To: CGI PHARMACEUTICALS, INC.
Reel/Frame 043548/0294 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2017
From: ARMISTEAD, DAVID M.; MITRA, SOUMYA
To: GILEAD CONNECTICUT, INC.
Reel/Frame 043548/0353 →
MERGER Recorded Sep 11, 2017
From: CGI PHARMACEUTICALS, INC.
To: GILEAD CONNECTICUT, INC.
Reel/Frame 043856/0646 →
Continuity (7)
Continuation 14300189 · Jun 9, 2014
Continuation 13868967 · Apr 23, 2013
Continuation 12632140 · Dec 7, 2009
Provisional Application 61240979 · Sep 9, 2009
Provisional Application 61140514 · Dec 23, 2008
Provisional Application 61120587 · Dec 8, 2008
Related Publication 20160031894A1 · Feb 4, 2016