IP Library Granted Patent US 11,471,685
Granted Patent B2
US 11,471,685 · App. 14/884,021 · Granted Oct 18, 2022

Obstructive sleep apnea treatment devices, systems and methods

Inventor: Stephen L. Bolea (Watertown, MN)
Assignee: LivaNova USA, Inc.
A61N1/36139A61F5/56A61F5/566A61N1/0556A61N1/3601A61N1/3611A61N1/3615A61B5/053A61B5/08A61B5/0809A61B5/0816A61B5/0826A61B5/4818A61B2017/248A61N1/3758A61N1/37229A61N1/37235
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Quick Facts
Patent No.
US 11,471,685
App. No.
14/884,021
Granted
Oct 18, 2022
Kind
B2
Abstract

A method of treating a patient, comprising: sensing a biological parameter indicative of respiration; analyzing the biological parameter to identify a respiratory cycle; identifying an inspiratory phase of the respiratory cycle; and delivering stimulation to a hypoglossal nerve of the patient, wherein stimulation is delivered if a duration of the inspiratory phase of the respiratory cycle is greater than a predetermined portion of a duration of the entire respiratory cycle.

Claims (39)

1. A method of treating a patient, comprising:

sensing, by circuitry, a biological parameter indicative of respiration;

analyzing, by the circuitry, the biological parameter to identify a respiratory cycle;

identifying, by the circuitry, an inspiratory phase of the respiratory cycle;

determining, by the circuitry, that a duration of the inspiratory phase of the respiratory cycle is at least a predetermined percentage of a duration of the entire respiratory cycle; and

delivering, by the circuitry, stimulation generated by a generator to a hypoglossal nerve of the patient via a lead coupled to the generator in response to determining the duration of the inspiratory phase of the respiratory cycle is at least the predetermined percentage of the duration of the entire respiratory cycle;

wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 25% of the duration of the entire respiratory cycle.

2. The method of claim 1 , wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 40% of the duration of the entire respiratory cycle.

3. The method of claim 1 , wherein the biological parameter includes impedance.

4. The method of claim 3 , wherein analyzing the biological parameter to identify a respiratory cycle includes identifying impedance peaks.

5. The method of claim 4 , further comprising comparing an amplitude of the impedance peaks to a threshold.

6. The method of claim 1 , wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 50% of the duration of the entire respiratory cycle.

7. An implantable medical device, comprising:

circuitry configured to:

sense a biological parameter indicative of respiration of a patient;

analyze the biological parameter to identify a respiratory cycle;

identify an inspiratory phase of the respiratory cycle;

determine that a duration of the inspiratory phase of the respiratory cycle is at least a predetermined percentage of a duration of the entire respiratory cycle; and

deliver stimulation generated by a generator to a hypoglossal nerve of the patient via a lead coupled to the generator in response to determining the duration of the inspiratory phase of the respiratory cycle is at least the predetermined percentage of the duration of the entire respiratory cycle;

wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 25% of the duration of the entire respiratory cycle.

8. The device of claim 7 , wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 40% of the duration of the entire respiratory cycle.

9. The device of claim 7 , wherein the biological parameter includes impedance.

10. The device of claim 9 , wherein analyzing the biological parameter to identify a respiratory cycle includes identifying impedance peaks.

11. The device of claim 10 , wherein the circuitry is further configured to compare an amplitude of the impedance peaks to a threshold.

12. The device of claim 7 , wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 50% of the duration of the entire respiratory cycle.

13. An implantable medical device, comprising:

a lead;

a generator coupled to the lead that generates stimulation to be provided to the lead; and

circuitry coupled to the generator, wherein the circuitry is configured to:

sense a biological parameter indicative of respiration of a patient;

analyze the biological parameter to identify a respiratory cycle;

identify an inspiratory phase of the respiratory cycle;

determine that a duration of the inspiratory phase of the respiratory cycle is at least a predetermined percentage of a duration of the entire respiratory cycle; and

deliver stimulation generated by the generator to a hypoglossal nerve of the patient via the lead coupled to the generator in response to determining the duration of the inspiratory phase of the respiratory cycle is at least the predetermined percentage of the duration of the entire respiratory cycle;

wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 50% of the duration of the entire respiratory cycle.

14. The device of claim 13 , wherein the predetermined percentage of the duration of the entire respiratory cycle is at least 40% of the duration of the entire respiratory cycle.

15. The device of claim 13 , wherein the biological parameter includes impedance.

16. The device of claim 15 , wherein analyzing the biological parameter to identify a respiratory cycle includes identifying impedance peaks.

17. The device of claim 16 , wherein the circuitry is further configured to compare an amplitude of the impedance peaks to a threshold.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: LIVANOVA USA, INC.
Reel/Frame 057552/0378 →
SECURITY INTEREST Recorded Aug 16, 2021
From: LIVANOVA USA, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0001 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: LIVANOVA USA, INC.
Reel/Frame 057189/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: LIVANOVA USA, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0784 →
CHANGE OF NAME Recorded Jun 29, 2020
From: CYBERONICS, INC.
To: LIVANOVA USA, INC.
Reel/Frame 053306/0229 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: LIVANOVA USA, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 053673/0675 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2015
From: BOLEA, STEPHEN L.
To: CYBERONICS, INC.
Reel/Frame 036822/0721 →