Topical dapsone and dapsone/adapalene compositions and methods for use thereof
Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include dapsone and/or adapalene in a polymeric viscosity builder. Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin. Use of the polymeric viscosity builder provides compositions with increased concentrations of diethylene glycol monoethyl ether relative to compositions without the polymeric viscosity builder.
1. A method for treating a dermatological condition selected from the group consisting of acne vulgaris and rosacea comprising administering to a subject having the dermatological condition selected from the group consisting of acne vulgaris and rosacea a topical pharmaceutical composition comprising:
about 7.5% w/w dapsone;
about 30% w/w to about 40% w/w diethylene glycol monoethyl ether;
about 2% w/w to about 6% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer; and
water;
wherein the topical pharmaceutical composition does not comprise adapalene.
2. The method of claim 1 , wherein the diethylene glycol monoethyl ether is present at a concentration of about 30% w/w.
3. The method of claim 1 , wherein the polymeric viscosity builder is present at a concentration of about 4% w/w.
4. The method of claim 1 , wherein the topical pharmaceutical composition further comprises methyl paraben.
5. The method of claim 1 wherein the dermatological condition is acne vulgaris.
6. A method for treating a dermatological condition selected from the group consisting of acne vulgaris and rosacea comprising administering to a subject having the dermatological condition selected from the group consisting of acne vulgaris and rosacea a topical pharmaceutical composition comprising:
about 7.5% w/w dapsone;
about 30% w/w diethylene glycol monoethyl ether;
about 4% w/w of a polymeric viscosity builder comprising acrylamide/sodium acryloyldimethyl taurate copolymer; and
water;
wherein the topical pharmaceutical composition does not comprise adapalene.
7. The method of claim 6 , wherein the topical pharmaceutical composition further comprises methyl paraben.
8. The method of claim 6 wherein the dermatological condition is acne vulgaris.