Anhydrous compositions
Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
1. An anhydrous composition consisting essentially of:
hydroxypropyl cellulose at a concentration in a range of 0.5% to about 2% by weight of the anhydrous composition,
ethanol or isopropyl alcohol at a concentration in a range of 45% to 90% by weight of the anhydrous composition,
hexylene glycol at a concentration of about 10% by weight of the anhydrous composition,
cyclomethicone at a concentration of about 2.5% by weight of the anhydrous composition, and
a nitric oxide (NO)-releasing compound at a concentration in a range of 0.01% to 40% by weight of the anhydrous composition.
2. The anhydrous composition of claim 1 , wherein the anhydrous composition comprises ethanol.
3. The anhydrous composition of claim 1 , wherein the anhydrous composition comprises isopropyl alcohol.
4. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration in a range of 0.01% to 30% by weight of the anhydrous composition.
5. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration in a range of 0.01% to 2% by weight of the anhydrous composition.
6. The anhydrous composition of claim 1 , wherein the hydroxypropyl cellulose is present in the anhydrous composition at a concentration in a range of 0.5% to about 1% by weight of the anhydrous composition.
7. The anhydrous composition of claim 1 , wherein the hydroxypropyl cellulose is present in the anhydrous composition at a concentration of about 1% by weight of the anhydrous composition.
8. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 1% by weight of the anhydrous composition.
9. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 2% by weight of the anhydrous composition.
10. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 4% by weight of the anhydrous composition.
11. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 8% by weight of the anhydrous composition.
12. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 12% by weight of the anhydrous composition.
13. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 16% by weight of the anhydrous composition.
14. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 20% by weight of the anhydrous composition.
15. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 24% by weight of the anhydrous composition.
16. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 30% by weight of the anhydrous composition.
17. The anhydrous composition of claim 1 , wherein the NO-releasing compound is present in the anhydrous composition at a concentration of about 32% by weight of the anhydrous composition.
18. The anhydrous composition of claim 1 , wherein the NO-releasing compound comprises diazeniumdiolated co-condensed silica particles.