Phenoxyethyl dihydro-1H-isoquinoline compounds

1. A compound of the formula:

wherein R is H or F;

or a pharmaceutically acceptable salt thereof.

2. The compound or salt according to claim 1 which is:

3. The compound or salt according to claim 2 which is:

4. The compound according to claim 3 which is 4-[(1S)-1-[[(3R)-2-(2-phenoxyethyl)-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]ethyl]benzoic acid:

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 4 which is 4-[(1S)-1-[[(3R)-2-(2-phenoxyethyl)-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]ethyl]benzoic acid:

6. The compound according to claim 3 which is 4-[(1S)-1-[[(3R)-2-(2-(4-fluorophenoxy)ethyl)-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]ethyl]benzoic acid:

or a pharmaceutically acceptable salt thereof.

7. A method of treating osteoarthritis in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound, or pharmaceutically acceptable salt thereof, according to claim 1 .

8. A method of treating rheumatoid arthritis in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound, or pharmaceutically acceptable salt thereof, according to claim 1 .

9. A method of treating pain associated with osteoarthritis or rheumatoid arthritis in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound, or a pharmaceutically acceptable salt thereof, according to claim 1 .

10. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 1 with one or more pharmaceutically acceptable carriers, diluents, or excipients.

11. A pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof according to claim 4 with one or more pharmaceutically acceptable carriers, diluents, or excipients.