Bicyclic compounds as ACC inhibitors and uses thereof

1. A compound of formula II selected from formula II-a, II-b, II-c, II-d, II-e, II-f, II-g, II-h, or II-i:

or a pharmaceutically acceptable salt thereof, wherein:

W is oxygen or sulfur;

R 1 is hydrogen or C 1-4 aliphatic, optionally substituted with one or more halogens, —OR, —SR, —N(R) 2 , —N(R)C(O)R, —C(O)N(R) 2 , —N(R)C(O)N(R) 2 , —N(R)C(O)OR, —OC(O)N(R) 2 , —N(R)SO 2 R, —SO 2 N(R) 2 , —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, or —SO 2 R;

R 2 is halogen, —R′, —OR, —SR, —N(R) 2 , —N(R)C(O)R, —C(O)N(R) 2 , —N(R)C(O)N(R) 2 , —N(R)C(O)OR, —OC(O)N(R) 2 , —N(R)SO 2 R, —SO 2 N(R) 2 , —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, —SO 2 R, —B(OR) 2 , or Hy, where Hy is selected from 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

each R is independently hydrogen, deuterium, or an optionally substituted group selected from C 1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

each R′ is independently an optionally substituted group selected from C 1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

R 3 is halogen, —CN, —OR, —SR, —N(R) 2 , —N(R)C(O)R, —C(O)N(R) 2 , —C(O)N(R)S(O) 2 R, —N(R)C(O)N(R) 2 , —N(R)C(O)OR, —OC(O)N(R) 2 , —N(R)SO 2 R, —SO 2 N(R) 2 , —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, —SO 2 R, —B(OR) 2 , or an optionally substituted ring selected from phenyl and 5-6 membered heterocyclyl or heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

R 4 is phenyl optionally substituted with n instances of R 8 or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is optionally substituted with n instances of R 8 ;

each of R 5 and R 5′ is independently —R, —OR, —SR, —N(R) 2 , —N(R)C(O)R, —C(O)N(R) 2 , —N(R)C(O)N(R) 2 , —N(R)C(O)OR, —OC(O)N(R) 2 , —N(R)SO 2 R, —SO 2 N(R) 2 , —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, or —SO 2 R; or R 5 and R 5′ are taken together to form a cyclopropylenyl, cyclobutylenyl, or oxetanyl group;

each of R 7 and R 7′ is independently —R, —OR 6 , —SR, —N(R) 2 , —N(R)C(O)R, —C(O)N(R) 2 , —N(R)C(O)N(R) 2 , —N(R)C(O)OR, —OC(O)N(R) 2 , —N(R)SO 2 R, —SO 2 N(R) 2 , —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, —SO 2 R, or —B(OR) 2 ; or R 7 and R 7′ are taken together to form a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, or a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

R 6 is —R, —C(O)N(R) 2 , or —C(O)R;

each R 8 is independently selected from halogen, —R, —OR, —SR, —N(R) 2 or deuterium;

R z is hydrogen, halogen, methyl, —CN, O, or S; and

n is 0-5;

provided that when a compound of formula II is formula II-b, II-f, II-h, or II-i, R z is O or S; and and when a compound of formula II is formula II-g, R z is hydrogen, halogen, methyl, or —CN.

2. The compound of claim 1 of formula II-a:

or a pharmaceutically acceptable salt thereof.

3. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

4. The compound of claim 1 of formula II-b:

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 of formula II-c:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 of formula II-d:

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 of formula II-e:

or a pharmaceutically acceptable salt thereof.

8. The compound of claim 1 of formula II-f:

or a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 of formula II-g:

or a pharmaceutically acceptable salt thereof.

10. The compound of claim 1 of formula II-h:

or a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 of formula II-i:

or a pharmaceutically acceptable salt thereof.

12. The compound of claim 1 , wherein R 2 is halogen.

13. The compound of claim 1 , wherein R 2 is —C(O)OR or —C(O)N(R) 2 .

14. The compound of claim 1 , wherein R 2 is Hy.

15. The compound of claim 1 , wherein R 2 is a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring.

16. The compound of claim 1 , wherein R 3 is —CN, —OR, —C(O)OR, —C(O)N(R) 2 , —SO 2 R, or an optionally substituted ring selected from phenyl and a 5-6 membered heterocyclyl or heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.

17. The compound of claim 1 , wherein R 3 is —C(O)OR.

18. The compound of claim 1 , wherein R 4 is phenyl, optionally substituted with n instances of R 8 .

19. The compound of claim 1 , wherein R z is hydrogen.

20. The compound of claim 1 , wherein R z is halogen, methyl, —CN, O, or S.

21. A compound of formula:

or a pharmaceutically acceptable salt thereof.