Fibrin-coated wound dressing

1. A wound dressing article comprising:

a flexible film layer;

a pressure-sensitive adhesive layer disposed on the flexible film layer;

an absorbent layer disposed between the flexible film layer and the pressure-sensitive adhesive layer; and

a fibrin powder layer disposed on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer;

the pressure sensitive adhesive layer extends into and through a portion of absorbent layer.

2. The article of claim 1 , wherein the fibrin powder comprises fibrin powder particles in the form of microspheres, amorphous particles, or a mixture thereof.

3. The article of claim 2 , wherein the fibrin powder particles have an average particle size in largest dimension of up to 100 micrometers.

4. The article of claim 1 , wherein a coating weight of the fibrin powder layer is in a range from 0.2 to 20 milligrams per cm 2 .

5. The article of claim 1 , wherein the fibrin powder layer contains fibrin in a range of 1 to 99 percent by weight, relative to a total weight of the fibrin powder layer.

6. The article of claim 1 , wherein the surface of the flexible film layer having the pressure-sensitive adhesive layer disposed thereon comprises a microstructured surface.

7. The article of claim 1 , wherein the pressure-sensitive adhesive layer is discontinuous.

8. The article of claim 1 , wherein the absorbent layer comprises a nonwoven or a fiber material.

9. The article of claim 8 , wherein the fiber material comprises sheath-core fiber having a central core of absorbent fiber and a sheath comprising pressure-sensitive adhesive.

10. The article of claim 1 , further comprising a release liner, wherein the fibrin powder layer is disposed between the pressure-sensitive adhesive layer and the release liner.

11. The article of claim 1 , wherein the flexible film layer is substantially transparent.

12. The article of claim 1 , wherein the fibrin powder layer comprise at least one additive.

13. An article comprising the wound dressing article of claim 1 positioned in a sealed packaged.

14. The article of claim 13 , wherein the sealed package comprises a sterile interior.

15. A method of making a wound dressing article, the method

comprising:

providing a flexible film layer;

disposing a pressure-sensitive adhesive layer on the flexible film layer;

disposing an absorbent layer between the flexible film layer and the pressure-sensitive adhesive layer;

forming a fibrin powder layer on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer to prepare the wound dressing article;

wherein the absorbent layer is an open cell foam having open cells;

wherein the pressure sensitive adhesive layer extends into and through a portion of the absorbent layer.

16. The method of claim 15 , wherein forming the fibrin powder comprises drying a fibrin-containing gel to form a dried fibrin-containing composition, and crushing the dried fibrin-containing composition to form the fibrin powder.

17. The method of claim 14 , further comprising subjecting the wound dressing article to terminal sterilization, wherein the terminal sterilization comprises gamma irradiation.

18. A method of treating a wound, comprising applying a wound dressing article according to claim 1 to an external wound on a mammal.

19. The method of claim 18 , wherein the mammal is a human.

20. The article of claim 1 , wherein the absorbent layer is an open cell foam.

21. A wound dressing article comprising:

a flexible film layer;

a pressure-sensitive adhesive layer disposed on the flexible film layer;

an absorbent layer disposed between the flexible film layer and the pressure-sensitive adhesive layer; and

a fibrin powder layer disposed on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer;

wherein the absorbent layer is an open cell foam having open cells;

wherein portions of the pressure-sensitive adhesive layer extends over the open cells.