Hollow microneedle with bevel opening

1. An article, comprising:

at least one microneedle, the at least one microneedle comprising:

a base;

an elongated body having a central axis;

a tip portion comprising a tip, a beveled surface, and a bevel opening in the beveled surface;

a first channel that extends axially from the bevel opening through at least a portion of the elongated body, wherein the first channel has a first wall that is substantially aligned with the central axis; and

a second channel that extends radially from the first channel, through a portion of the microneedle between the tip and a portion of the beveled surface distant from the tip and does not extend through any other portion of the microneedle, to the bevel opening, wherein the second channel has a second wall that is oriented substantially orthogonal to the central axis;

wherein the first channel and second channel merge to form the bevel opening; and wherein

the beveled surface is defined by a bevel edge surrounding the beveled surface, wherein the bevel opening is defined by an opening edge surrounding the bevel opening, and wherein no portion of the opening edge is coincident with any portion of the bevel edge.

2. The article of claim 1 , wherein the article further comprises a substrate having a first side and a second side, wherein the at least one microneedle extends from the first side of the substrate, wherein the first channel extends from the bevel opening through the elongated body to a second opening on the second side of the substrate.

3. The article of claim 1 , wherein the at least one microneedle comprises a plurality of microneedles.

4. The article of claim 1 , wherein the tip portion comprises plurality of intersecting planes.

5. The article of claim 1 , wherein a bevel face defines a first plane, wherein a first two-dimensional area defined by the bevel opening is larger than a second two-dimensional area defined by a cross-sectional area of the first channel taken along the first plane.

6. A method of use of the article of claim 1 , comprising injecting fluid from the article into a body.

7. A method of use of the article of claim 1 , comprising extracting fluid from a body to the article.

8. A method of making an article of claim 1 comprising: providing a first mold half comprising at least one cavity; wherein the at least one cavity includes a cavity opening and a cavity surface having a first projection extending therefrom toward the cavity opening; wherein the first projection defines a first segment of a hollow channel, the first segment extending into the body of the microneedle from the base; wherein the first projection comprises a first longitudinal axis; providing a second mold half comprising at least one second projection extending therefrom; wherein the at least one second projection defines the tip portion of the microneedle and a second segment of the hollow channel, the second segment extending into the body of the microneedle from the bevel opening proximate the tip of the at least one microneedle; wherein the at least one second projection comprises a second longitudinal axis; wherein the second projection is shaped and dimensioned to define the tip portion; wherein the second projection is shaped and dimensioned such that the first channel and second channel merge to form the bevel opening; contacting at least the first mold surface or the second mold surface with moldable material; and inserting the second projection into the at least one cavity.

9. The method of claim 8 , wherein the second projection is inserted into the at least one cavity before contacting at least the first mold surface or the second mold surface with the moldable material.

10. The method of claim 8 , wherein at least the first mold surface or the second mold surface is contacted with the moldable material before inserting the second projection into the at least one cavity.

11. The method of claim 8 , wherein the moldable material comprises a metal, a ceramic, or a polymeric material.

12. The method of claim 8 , wherein the at least one cavity has a cavity aspect ratio (cavity length to cavity base width) of at least 1.5 to 1.

13. The method of claim 8 , wherein the first mold half comprises a plurality of the at least one cavities, wherein the second mold half comprises a plurality of the at least one second projections, wherein the plurality of second projections is aligned to be inserted simultaneously into the plurality of cavities.

14. An article, comprising:

at least one microneedle, the at least one microneedle comprising:

a base;

an elongated body having a central axis;

a tip portion comprising a tip, a beveled surface, and a bevel opening in the beveled surface;

a first channel that extends axially from the bevel opening through at least a portion of the elongated body, wherein the first channel has a first wall that is substantially aligned with the central axis; and

a second channel that extends radially from the first channel, through a portion of the microneedle between the tip and a portion of the beveled surface distant from the tip and does not extend through any other portion of the microneedle, to the bevel opening, wherein the second channel has a second wall that is oriented substantially orthogonal to the central axis;

wherein the first channel and second channel merge to form the bevel opening;

and wherein the beveled surface is defined by a bevel edge surrounding the beveled surface, wherein the bevel opening is defined by an opening edge surrounding the bevel opening, and wherein at least a portion of the opening edge is coincident with a portion of the bevel edge.

15. The article of claim 14 , wherein the article further comprises a substrate having a first side and a second side, wherein the at least one microneedle extends from the first side of the substrate, wherein the first channel extends from the bevel opening through the elongated body to a second opening on the second side of the substrate.

16. The article of claim 14 , wherein the at least one microneedle comprises a plurality of microneedles.

17. The article of claim 14 , wherein the tip portion comprises plurality of intersecting planes.

18. The article of claim 14 , wherein a bevel face defines a first plane, wherein a first two-dimensional area defined by the bevel opening is larger than a second two-dimensional area defined by a cross-sectional area of the first channel taken along the first plane.

19. A method of making an article of claim 14 comprising: providing a first mold half comprising at least one cavity; wherein the at least one cavity includes a cavity opening and a cavity surface having a first projection extending therefrom toward the cavity opening; wherein the first projection defines a first segment of a hollow channel, the first segment extending into the body of the microneedle from the base; wherein the first projection comprises a first longitudinal axis; providing a second mold half comprising at least one second projection extending therefrom; wherein the at least one second projection defines the tip portion of the microneedle and a second segment of the hollow channel, the second segment extending into the body of the microneedle from the bevel opening proximate the tip of the at least one microneedle; wherein the at least one second projection comprises a second longitudinal axis; wherein the second projection is shaped and dimensioned to define the tip portion; wherein the second projection is shaped and dimensioned such that the first channel and second channel merge to form the bevel opening; contacting at least the first mold surface or the second mold surface with moldable material; and inserting the second projection into the at least one cavity.

20. The method of claim 19 , wherein the second projection is inserted into the at least one cavity before contacting at least the first mold surface or the second mold surface with the moldable material.

21. The method of claim 19 , wherein at least the first mold surface or the second mold surface is contacted with the moldable material before inserting the second projection into the at least one cavity.

22. The method of claim 19 , wherein the moldable material comprises a metal, a ceramic, or a polymeric material.

23. The method of claim 19 , wherein the at least one cavity has a cavity aspect ratio (cavity length to cavity base width) of at least 1.5 to 1.

24. The method of claim 19 , wherein the first mold half comprises a plurality of the at least one cavities, wherein the second mold half comprises a plurality of the at least one second projections, wherein the plurality of second projections is aligned to be inserted simultaneously into the plurality of cavities.