IP Library Patent Application 14908756
Patent Application
App. No. 14/908,756

Assay cartridge processing systems and methods and associated assay cartridges

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Quick Facts
Patent No.
US None
App. No.
14/908,756
Abstract

An assay cartridge processing system includes an agitation source for agitating assay components within an assay cartridge, and a timing module for controlling timing of agitation. An assay cartridge processing method includes applying agitation to an assay cartridge to mix assay components, and electronically controlling timing of agitation. An assay cartridge processing system includes a puncture device for puncturing an assay cartridge to allow fluid flow, and a timing module for controlling timing of puncturing. An assay cartridge processing method includes puncturing a vent of a capillary channel of an assay cartridge to allow fluid flow from an inlet port of the assay cartridge into the capillary channel, and electronically controlling timing of the step of puncturing. An assay cartridge includes a capillary channel, an inlet port, and a vent including a frangible seal for preventing fluid flow from into the capillary channel when the frangible seal is intact.

Claims (45)

1 . An assay cartridge processing system comprising:

a fixture for holding an assay cartridge; and

at least one agitation source, integrated with the fixture, for mixing assay components within a fluidic chamber of the assay cartridge.

2 . The assay cartridge processing system of claim 1 , the at least one agitation source including at least one mechanical oscillator for vibrating the assay cartridge through mechanical coupling between the mechanical oscillator and an external surface of the assay cartridge.

3 . The assay cartridge processing system of claim 2 , the mechanical oscillator being at least intermittently in direct contact with the external surface.

4 . The assay cartridge processing system of claim 2 , the mechanical oscillator being at least intermittently coupled with the external surface via the fixture.

5 . The assay cartridge processing system of claim 2 , the mechanical oscillator including at least one of a piezoelectric material, an offset-weight motor, and an induction coil vibrator.

6 . The assay cartridge processing system of claim 1 , the at least one agitation source including an oscillating-magnetic-field generator for generating an oscillating magnetic field to magnetically induce motion of the assay cartridge by inducing motion of a magnetic material rigidly coupled thereto.

7 . The assay cartridge processing system of claim 1 , the at least one agitation source including a magnetic field generator for generating a temporally varying magnetic field to induce motion of an oblong magnetic stir element within an inlet port of the fluidic chamber.

8 . (canceled)

9 . The assay cartridge processing system of claim 7 , the magnetic field generator being configured to produce spinning movement of the oblong magnetic stir element.

10 . The assay cartridge processing system of claim 1 , further comprising a puncture device, integrated with the fixture, for puncturing a vent of the fluidic chamber to allow fluid flow through the fluidic chamber.

11 . The assay cartridge processing system of claim 10 , further comprising:

a sensor for sensing insertion of the assay cartridge into the fixture; and

electronic circuitry, communicatively coupled with the sensor and the puncture device, for controlling said puncturing at least partly based upon insertion of the assay cartridge into the fixture as sensed by the sensor.

12 . (canceled)

13 . The assay cartridge processing system of claim 1 , further comprising:

a sensor for sensing full insertion of the assay cartridge into the fixture; and

electronic circuitry for controlling agitation by the agitation source at least partly based upon insertion of the assay cartridge into the fixture as sensed by the sensor.

14 . (canceled)

15 . An assay cartridge processing method comprising:

holding an assay cartridge in a fixture; and

agitating the assay cartridge, using an agitation source integrated with the fixture, to mix assay components in the assay cartridge.

16 . The assay cartridge processing method of claim 15 , further comprising:

sensing full insertion of the assay cartridge into the fixture; and

performing the step of agitating at least partly based upon said sensing full insertion.

17 . The assay cartridge processing method of claim 15 ,

the step of holding comprising holding the assay cartridge in the fixture such that the assay cartridge is movable relative to the fixture; and

the step of agitating comprising vibrating an external surface of the assay cartridge through physical coupling of the external surface to a mechanical oscillator integrated with the fixture.

18 . The assay cartridge processing method of claim 15 , the step of agitating comprising:

generating a temporally varying magnetic field to induce motion of an oblong magnetic stir element in the assay cartridge.

19 . The assay cartridge processing method of claim 18 , the step of generating comprising generating the temporally varying magnetic field to induce motion of the oblong magnetic stir element within an inlet port of the assay cartridge.

20 . The assay cartridge processing method of claim 15 , further comprising puncturing a vent of a capillary channel of the assay cartridge, using a puncture device integrated with the fixture, to allow flow of the assay components, mixed in the step of agitating, from the inlet port into the capillary channel.

21 . (canceled)

22 . The assay cartridge processing method of claim 20 , further comprising:

sensing insertion of the assay cartridge into the fixture; and

performing one or both of the step of puncturing and the step of agitating based at least in part upon said sensing insertion.

23 - 24 . (canceled)

25 . An assay cartridge processing system comprising:

a fixture for holding an assay cartridge; and

a puncture device, integrated with the fixture, for puncturing a fluidic chamber of the assay cartridge to allow fluid flow through the fluidic chamber, the puncture device being configured to puncture the fluidic chamber through physical contact between the puncture device and the fluidic chamber.

26 . The assay cartridge processing system of claim 25 , further comprising:

a sensor for sensing insertion of the assay cartridge into the fixture; and

electronic circuitry for controlling said puncturing at least partly based upon insertion of the assay cartridge into the fixture as sensed by the sensor.

27 - 39 . (canceled)

Assignments (4)
MERGER Recorded May 19, 2025
From: MBIO DIAGNOSTICS, INC.
To: HESKA CORPORATION
Reel/Frame 071338/0695 →
MERGER Recorded May 19, 2025
From: HESKA CORPORATION
To: ANTECH DIAGNOSTICS, INC.
Reel/Frame 071338/0716 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2025
From: ANTECH DIAGNOSTICS, INC.
To: MARS, INCORPORATED
Reel/Frame 071338/0783 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2016
From: GIVENS, MONIQUE; ROWLEY, KEAGAN B.; VOGEL, KURT R.; SUPON, FRANK WILLIAM; LOCHHEAD, MICHAEL J.
To: MBIO DIAGNOSTICS, INC.
Reel/Frame 040454/0796 →