Compounds for enhancing the cognitive function
View Patent ↗The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for enhancing the cognitive function or to counteract cognitive decline.
1. A compound of formula (I)
wherein
R 1 is either a 3,4,5-trifluorophenyl or a 3-cyanophenyl group;
R 2 is either cyano or chlorine;
or a tautomer, isomer or salt thereof.
2. The compound according to claim 1 , wherein the R 1 group of formula (I) is in a 4R configuration.
3. The compound according to claim 2 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.
4. The compound according to claim 1 , wherein the R 1 group of formula (I) is in a 4S configuration.
5. The compound according to claim 4 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.
6. The compound according to claim 1 , wherein the R 1 group is a 3,4,5-trifluorophenyl moiety.
7. The compound according to claim 1 that is
(4R)-1-[(5-chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one;
1-{[(4R)-2-oxo-4-(3,4,5-trifluorophenyl)pyrrolidin-1-yl]methyl}-1H-1,2,4-triazole-5-carbonitrile; or
(+)-3-{1-[(5-chloro-1H-1,2,4-triazol-1-yl)methyl]-5-oxopyrrolidin-3-yl}benzonitrile.
8. A pharmaceutical composition containing a compound according to claim 1 together with a suitable pharmaceutically acceptable excipient.
9. A pharmaceutical composition containing a compound according to claim 2 together with a suitable pharmaceutically acceptable excipient.
10. A pharmaceutical composition containing a compound according to claim 7 together with a suitable pharmaceutically acceptable excipient.
11. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 1 .
12. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 2 .
13. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 4 .
14. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 6 .
15. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 7 .
16. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 3 .
17. A method of treating Alzheimer's disease in a human comprising administering to the human an effective amount of a compound according to claim 5 .