Cartridge portion of transdermal drug delivery apparatus and methods
View Patent ↗A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.
1. A cartridge for supplying fluid in a transdermal drug delivery apparatus, the cartridge comprising:
a body at least partially defining
an interior for containing the fluid,
a first cavity including a cylindrical section and a frustoconical section, the cylindrical section tapering to the frustoconical section,
a second cavity,
a passageway connected between the cylindrical section of the first cavity and the second cavity, and
first and second openings to the interior of the body,
wherein the first and second openings are respectively defined by opposite first and second ends of the body, wherein the first opening is contiguous with the first cavity, and the second opening is contiguous with the second cavity;
a self-sealing member at least partially closing the first opening; and
a movable member at least partially closing the second opening, wherein at least a portion of the movable member is configured for being urged into the interior of the body for increasing pressure within the interior of the body.
2. The cartridge according to claim 1 , wherein the self-sealing member comprises a self-sealing septum.
3. The cartridge according to claim 1 , wherein:
the movable member comprises a deformable membrane, and
at least a portion of the deformable membrane is configured for being urged into the interior of the body for increasing pressure within the interior of the body.
4. The cartridge according to claim 3 , wherein the deformable membrane is a flexible membrane.
5. The cartridge according to claim 1 , wherein:
the self-sealing member is part of a first closure mounted proximate the first end for closing the first opening; and
the movable member is part of a second closure mounted proximate the second end for closing the second opening.
6. The cartridge according to claim 1 in combination with the fluid, wherein the fluid comprises a drug formulation positioned in the interior of the body.
7. The cartridge according to claim 1 , wherein:
the second cavity is at least partially defined by a substantially concave wall; and
the passageway is open proximate a central portion of the substantially concave wall.
8. The cartridge according to claim 7 , wherein:
the substantially concave wall is a substantially bowl-shaped wall; and
the passageway is open proximate a central portion of the substantially bowl-shaped wall.
9. The cartridge according to claim 7 in combination with a controller, wherein:
the movable member comprises a deformable member;
the controller comprises a pushing mechanism with a domed head for pressing the deformable member against the substantially concave wall; and
the domed head and the second cavity are configured complementary with respect to one another for substantially emptying the second cavity.
10. The cartridge according to claim 1 in combination with a controller, wherein:
the cartridge and the controller are connected to one another by way of at least one snap-fit connector; and
the controller is configured for urging the movable member into the interior of the body for increasing pressure within the interior of the body.
11. The cartridge according to claim 1 , further comprising:
a first connector part extending outwardly from the body for moving with the body, and
a second connector part extending outwardly from the body for moving with the body,
wherein the first and second connector parts are spaced apart from one another along a length of the body.
12. The cartridge according to claim 1 , further comprising:
an outwardly oriented first connector part configured for moving with the body, and
an outwardly oriented second connector part configured for moving with the body,
wherein the first and second connector parts are spaced apart from one another along a length of the body.
13. The cartridge according to claim 12 , wherein each of the first and second connector parts is a snap-fit connector part.
14. The cartridge according to claim 12 , wherein:
the first connector part extends outwardly relative to the body, and
the second connector part extends outwardly relative to the body.
15. The cartridge according to claim 12 , wherein:
the first connector part comprises an annular groove, and
the second connector part comprises an annular groove.
16. The cartridge according to claim 1 in combination with the transdermal drug delivery apparatus, wherein the cartridge is mounted between a controller and a receptacle of the transdermal drug delivery apparatus.
17. A cartridge for supplying fluid in a transdermal drug delivery apparatus, the cartridge comprising:
a body including a substantially concave wall, wherein
the substantially concave wall at least partially defines an interior of the body for containing the fluid,
the body at least partially defines a first cavity including a cylindrical section and a frustoconical section, the cylindrical section tapering to the frustoconical section, a second cavity, and a passageway connected between the cylindrical section of the first cavity and the second cavity,
the body at least partially defines opposite first and second openings to the interior of the body, wherein the first opening is contiguous with the first cavity, and the second opening is contiguous with the second cavity, and
the second opening is proximate the substantially concave wall;
a self-sealing member at least partially closing the first opening; and
a deformable member at least partially closing the second opening, wherein the deformable member is configured for being urged into the interior of the body and at least partially conforming to the concave wall for increasing pressure within the interior of the body.
18. The cartridge according to claim 17 , wherein the self-sealing member comprises a self-sealing septum.
19. The cartridge according to claim 17 , wherein the deformable member comprises a deformable membrane, and at least a portion of the deformable membrane is configured for being urged against the substantially concave wall.
20. The cartridge according to claim 17 , wherein:
the self-sealing member is part of a first closure mounted proximate a first end for closing the first opening; and
the deformable member is part of a second closure mounted proximate a second end for closing the second opening.
21. The cartridge according to claim 17 in combination with the fluid, wherein the fluid comprises a drug formulation positioned in the interior of the body.
22. The cartridge according to claim 17 , further comprising:
a first connector part extending outwardly from the body for moving with the body, and
a second connector part extending outwardly from the body for moving with the body,
wherein the first and second connector parts are spaced apart from one another along a length of the body.
23. The cartridge according to claim 22 , wherein each of the first and second connector parts is a snap-fit connector part.
24. The cartridge according to claim 22 , in combination with a controller, wherein:
the cartridge and the controller are connected to one another by way of at least one snap-fit connector; and
the controller is configured for urging the deformable member into the interior of the body for increasing pressure within the interior of the body.
25. The cartridge according to claim 17 in combination with a controller, wherein:
the controller comprises a pushing mechanism with a domed head for pressing the deformable member against the substantially concave wall; and
the domed head and the second cavity are configured complementary with respect to one another for substantially emptying the second cavity.
26. The cartridge according to claim 17 , wherein:
the second cavity is at least partially defined by the substantially concave wall; and
the passageway is open proximate a central portion of the substantially concave wall.
27. The cartridge according to claim 26 , wherein:
the substantially concave wall is a substantially bowl-shaped wall; and
the passageway is open proximate a central portion of the substantially bowl-shaped wall.
28. The cartridge according to claim 17 in combination with the transdermal drug delivery apparatus, wherein the cartridge is mounted between a controller and a receptacle of the transdermal drug delivery apparatus.