Conductive polymeric coatings, medical devices, coating solutions and methods
View Patent ↗The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.
1. A coating solution for forming a conductive polymer layer consisting of:
a conductive monomer, wherein the conductive monomer comprises 3,4-ethylenedioxythiophene (EDOT), a functionalized derivative of EDOT, or a mixture thereof;
at least one photoreactive component comprising an anionic photoreactive hydrophilic polymer containing polyacrylamide and photoreactive groups;
a non-charged hydrophilic polymer derived from 1-vinyl-2-pyrrolidone (PVP) comprising photoreactive functional groups;
at least one solvent; and
a surfactant.
2. The coating solution of claim 1 , wherein the conductive monomer comprises the functionalized derivative of EDOT selected from the group consisting of hydroxymethyl-EDOT, EDOT-vinyl, EDOT-ether allyl, EDOT-COOH, EDOT-MeOH, EDOT-silane, EDOT-vinyl, EDOT-acrylate, EDOT-sulfonate, EDOT-amine, EDOT-amide, bi-EDOT, tri-EDOT, and combinations thereof.
3. The coating solution of claim 1 , wherein a weight ratio of the anionic photoreactive hydrophilic polymer and the non-charged hydrophilic polymer is between about 1:10 and about 10:1.
4. The coating solution of claim 1 , the at least one photoreactive component further comprising an anionic photoreactive cross-linking agent, the anionic photoreactive cross-linking agent comprising sulfonate, carboxylate, phosphonate, or phosphate groups, or combinations thereof.
5. The coating solution of claim 1 , the at least one photoreactive component further comprising an anionic photoreactive cross-linking agent, and the anionic photoreactive cross-linking agent comprising disodium 4,5-bis[(4-benzoylbenzyl)oxy]-1,3-benzenedisulfonate or sodium bis(4-benzoylphenyl) phosphate; or the photoreactive component comprising the anionic photoreactive hydrophilic polymer, the anionic photoreactive hydrophilic polymer comprising poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide] or N-acetylated poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide]-co-methoxy poly(ethylene glycol).
6. The coating solution of claim 1 , wherein the anionic photoreactive hydrophilic polymer further comprises sulfonate groups.
7. The coating solution of claim 1 , the surfactant being selected from polaxamers, polyoxyethylene alkyl ethers, polysorbitan, or polyoxyethylene derivatives of sorbitan monolaurate.
8. The coating solution of claim 1 , the at least one solvent comprising an aprotic organic solvent or a polar organic solvent.
9. The coating solution of claim 1 , wherein the at least one solvent comprises at least one selected from the group consisting of acetonitrile, dichloromethane, dimethylsulfoxide, acetone, dimethylformamide, isopropanol, methanol, ethanol, water, and combinations thereof.
10. An electrically conductive coating comprising a reaction product of a polymerization mixture consisting of:
a conductive monomer, wherein the conductive monomer comprises 3,4-ethylenedioxythiophene (EDOT), a functionalized derivative of EDOT, or a mixture thereof;
at least one photoreactive component comprising an anionic photoreactive hydrophilic polymer containing polyacrylamide and photoreactive groups;
a non-charged hydrophilic polymer derived from 1-vinyl-2-pyrrolidone (PVP) comprising photoreactive functional groups;
at least one solvent and
a surfactant.
11. A coated electrode comprising an electrode and the electrically conductive coating of claim 10 , wherein the electrically conductive coating is disposed over at least a portion of the electrode.