NASAL DEVICES
A nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.
1 - 403 . (canceled)
404 . A nasal delivery device for delivering a substance to a nasal airway of a subject, comprising:
a nosepiece unit configured to fit in a nostril of the subject, the nosepiece unit including a nozzle through which the substance is delivered to the nasal airway of the subject;
a mouthpiece unit configured to fit in a mouth of the subject and receive a flow of exhalation breath from the subject, whereby exhalation by the subject causes closure of a oropharyngeal velum of the subject;
a flow channel fluidly connecting the nosepiece unit and the mouthpiece unit, whereby exhalation breath flows from the mouthpiece unit through the fluid channel and out of the nosepiece unit;
at least one cuff member, which includes at least one lobe, configured to extend into a region of the nasal cavity of the subject and engage an inner wall of the nasal cavity of the subject when fitted in the nasal cavity of the subject; and
a delivery unit for delivering the substance through the nozzle of the nosepiece unit.
405 . The delivery device of claim 404 , wherein the substance is a powder.
406 . The delivery device of claim 405 , wherein the powder is a pharmaceutical.
407 . The delivery device of claim 406 , wherein the powder is an anti-migraine composition.
408 . The delivery device of claim 404 , wherein the substance is delivered to a site within the nasal airway of the subject.
409 . The delivery device of claim 408 , wherein the site includes at least a part of the inferior meatus.
410 . The delivery device of claim 408 , wherein the site includes at least a part of the middle meatus.
411 . The delivery device of claim 408 , wherein the site includes an inferior part of the middle meatus.
412 . The delivery device of claim 408 , wherein the site includes at least a part of the superior meatus.
413 . The delivery device of claim 408 , wherein the site includes at least a part of the inferior nasal concha.
414 . The delivery device of claim 408 , wherein the site includes at least a part of the middle nasal concha.
415 . The delivery device of claim 408 , wherein the site includes at least a part of the superior nasal concha.
416 . The delivery device of claim 408 , wherein the site includes at least a part of the olfactory region.
417 . The delivery device of claim 408 , wherein the site includes at least a sinus ostia.
418 . The delivery device of claim 408 , wherein the site includes at a least sinus infundibulum.
419 . The delivery device of claim 408 , wherein the site includes at least a part of the epipharynx.
420 . The delivery device of claim 408 , wherein the site includes at least adenoids.
421 . The delivery device of claim 408 , wherein the site includes at least tubal ostia.
422 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 80 μm.
423 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 50 μm.
424 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 30 μm.
425 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 10 μm to about 30 μm.
426 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 10 μm to about 20 μm.
427 . The delivery device of claim 404 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 15 μm to about 30 μm.
428 . The delivery device of claim 404 , wherein the nosepiece is a replaceable unit.
429 . The delivery device of claim 404 , wherein the at least one cuff member includes a plurality of lobes, the at least one cuff member configured to at least partially block the nasal cavity of the subject.
430 . The delivery device of claim 404 , wherein the delivery unit is configured to deliver the substance to the nozzle in response to the flow of exhalation breath.
431 . A nasal delivery device for delivering a substance to a nasal airway of a subject, comprising:
a nosepiece unit configured to fit in a nostril of the subject, the nosepiece unit including a nozzle through which the substance is delivered to the nasal airway of the subject;
a mouthpiece unit configured to fit in a mouth of the subject and receive a flow of exhalation breath from the subject, whereby exhalation by the subject causes closure of a oropharyngeal velum of the subject;
a flow channel fluidly connecting the nosepiece unit and the mouthpiece unit, whereby exhalation breath flows from the mouthpiece unit through the fluid channel and out of the nosepiece unit; and
a delivery unit for delivering the substance through the nozzle of the nosepiece unit;
wherein the substance is a powder, a pharmaceutical, and an anti-migraine composition.
432 . The delivery device of claim 431 , wherein the substance is delivered to a site within the nasal airway of the subject.
433 . The delivery device of claim 432 , wherein the site includes at least a part of the inferior meatus.
434 . The delivery device of claim 432 , wherein the site includes at least a part of the middle meatus.
435 . The delivery device of claim 432 , wherein the site includes an inferior part of the middle meatus.
436 . The delivery device of claim 432 , wherein the site includes at least a part of the superior meatus.
437 . The delivery device of claim 432 , wherein the site includes at least a part of the inferior nasal concha.
438 . The delivery device of claim 432 , wherein the site includes at least a part of the middle nasal concha.
439 . The delivery device of claim 432 , wherein the site includes at least a part of the superior nasal concha.
440 . The delivery device of claim 432 , wherein the site includes at least a part of the olfactory region.
441 . The delivery device of claim 432 , wherein the site includes at least a sinus ostia.
442 . The delivery device of claim 432 , wherein the site includes at a least sinus infundibulum.
443 . The delivery device of claim 432 , wherein the site includes at least a part of the epipharynx.
444 . The delivery device of claim 432 , wherein the site includes at least adenoids.
445 . The delivery device of claim 432 , wherein the site includes at least tubal ostia.
446 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 80 μm.
447 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 50 μm.
448 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 1 μm to about 30 μm.
449 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 10 μm to about 30 μm.
450 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 10 μm to about 20 μm.
451 . The delivery device of claim 431 , wherein more than half of the particles in a particle size distribution of the substance are in the range of about 15 μm to about 30 μm.
452 . The delivery device of claim 431 , further comprising at least one cuff member, wherein the at least one cuff member includes a plurality of lobes, the at least one cuff member configured to at least partially block the nasal cavity of the subject.
453 . The delivery device of claim 431 , wherein the delivery unit is configured to deliver the substance to the nozzle in response to the flow of exhalation breath.